Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats

Yong-hua Zhao; You-hua Xu; Ying Guan; Ping Xiang

doi:10.1007/s11655-010-0524-y

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Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats

Updated：2021-08-27

- Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats
- Chinese Journal of Integrative Medicine Vol. 16, Issue 4, Pages: 344-347(2010)
- Affiliations：
  
  Faculty of Chinese Medicine, Macau University of Science and Technology, Macao,China
- Author bio：
- Funds：
  
  Supported by Science and Technology Development Fund of Macao Special Administrative Region (No.105/2005/A)
- DOI：10.1007/s11655-010-0524-y
  CLC：
- Published：2010，
  
  Published Online：10 August 2010，
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Zhao, Yh., Xu, Yh., Guan, Y. et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats., Chin. J. Integr. Med. 16, 344–347 (2010). https://doi.org/10.1007/s11655-010-0524-y

Yong-hua Zhao, You-hua Xu, Ying Guan, et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats. [J]. Chinese Journal of Integrative Medicine 16(4):344-347(2010)
Zhao, Yh., Xu, Yh., Guan, Y. et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats., Chin. J. Integr. Med. 16, 344–347 (2010). https://doi.org/10.1007/s11655-010-0524-y DOI：

Yong-hua Zhao, You-hua Xu, Ying Guan, et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats. [J]. Chinese Journal of Integrative Medicine 16(4):344-347(2010) DOI： 10.1007/s11655-010-0524-y.

摘要

To observe the effects of Yinian Jiangya Decoction (颐年降压饮

YNJYD) on cytokine secretion in spontaneoulsy hypertensive rats (SHRs) vascular endothelium. Aortic endothelial cells (ECs) were primarily cultured from SHRs; male SD rats were treated with different doses (high

medium

and low doses) of YNJYD

the blood was collected on the 21st day

and then

the serum was separated. ECs were cocultured with the serum for different time courses

and the culture supernatant concentrations of endothelin (ET)-1

nitric oxide (NO)

tissue-type plasminogen activator (t-PA)

and plasminogen activator inhibitor (PAI-1) were determined by ABC-ELISA methods. ET-1

t-PA

and PAI-1 levels in endothelial cell culture supernatant were increased in a time-dependent manner; YNJYD could significantly elevate NO and t-PA expressions in ECs

while ET-1 and PAI-1 expressions were dramatically decreased; these effects of YNJYD were in a concentration-dependent manner. The therapeutic effect of YNJYD on hypertension is attributed to its effect on regulating vessel dilation and blood coagulation

in which ET-1/NO and PAI-1/t-PA are two pairs of pivotal mediators.

Abstract

To observe the effects of Yinian Jiangya Decoction (颐年降压饮

medium

and low doses) of YNJYD

the blood was collected on the 21st day

and then

the serum was separated. ECs were cocultured with the serum for different time courses

and the culture supernatant concentrations of endothelin (ET)-1

nitric oxide (NO)

tissue-type plasminogen activator (t-PA)

and plasminogen activator inhibitor (PAI-1) were determined by ABC-ELISA methods. ET-1

t-PA

and PAI-1 levels in endothelial cell culture supernatant were increased in a time-dependent manner; YNJYD could significantly elevate NO and t-PA expressions in ECs

in which ET-1/NO and PAI-1/t-PA are two pairs of pivotal mediators.

关键词

Yinian Jiangya Decoctionendothelial cellcytokine

Keywords

Yinian Jiangya Decoctionendothelial cellcytokine

references

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Department of Gerontology, Beijing Friendship Hospital, Capital Medical University

Library of Guangzhou University of Chinese Medicine

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Department of Cerebropathia, the First Affiliated Hospital of Guangzhou University of Chinese Medicine

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