Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension

Guang-wei Zhong; Min-jing Chen; Yan-hong Luo; Ling-li Xiang; Qi-ying Xie; Yun-hui Li; Chen Zhang; Feng Gao

doi:10.1007/s11655-011-0761-6

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Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension

Updated：2021-08-27

- Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension
- Chinese Journal of Integrative Medicine Vol. 17, Issue 6, Pages: 414-420(2011)
- Affiliations：
  
  1. Institute of Integrated Traditional and Western Medicine, Xiangya Hospital, Central South University,Changsha,China
  2. Department of Pathology, The People’s Hospital of Xiangxi Autonomous Region, Jishou,Hunan Province,China
  3. Institute of Hypertensive Disease, Xiangya Hospital, Central South University,Changsha,China
  4. Department of Cardiopathy, The Second People’s Hospital of Hunan Province,Changsha,China
  5. Department of Echocardiography, The Third Xiangya Hospital, Central South University,Changsha,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30500644;304071125) and the Science and Technology Projects of Traditional Chinese Medicine of Hunan Province (No. 2009047)
- DOI：10.1007/s11655-011-0761-6
  CLC：
- Published：2011，
  
  Published Online：10 June 2011，
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Zhong, Gw., Chen, Mj., Luo, Yh. et al. Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension., Chin. J. Integr. Med. 17, 414–420 (2011). https://doi.org/10.1007/s11655-011-0761-6

Guang-wei Zhong, Min-jing Chen, Yan-hong Luo, et al. Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension. [J]. Chinese Journal of Integrative Medicine 17(6):414-420(2011)
Zhong, Gw., Chen, Mj., Luo, Yh. et al. Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension., Chin. J. Integr. Med. 17, 414–420 (2011). https://doi.org/10.1007/s11655-011-0761-6 DOI：

Guang-wei Zhong, Min-jing Chen, Yan-hong Luo, et al. Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension. [J]. Chinese Journal of Integrative Medicine 17(6):414-420(2011) DOI： 10.1007/s11655-011-0761-6.

摘要

To observe the effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang (平肝潜阳

CGSHY) on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension (EH). Adopting a parallel

randomized design

sixty-four patients with EH of stages I and II were randomly divided into two groups according to a random number table

with 32 in each group. The patients in the treatment group were treated with CGSHY and those in the control group were treated with Enalapril. All patients were given 24-h ambulatory blood pressure monitoring (ABPM) before and after a 12-week treatment. Trough/peak (T/P) ratios of systolic and diastolic blood pressure (SBP & DBP) of each group were calculated. The circadian rhythm of their blood pressure was observed at the same time. The changes in elasticity of the carotid artery in the patients

including stiffness parameter (β)

pressure-strain elastic modulus (Ep)

arterial compliance (AC)

augmentation index (AI)

and pulse wave velocity (PVWβ) were determined by the echo-tracking technique before and after a 12-week treatment. In the meantime

their levels of nitric oxide (NO) and endothelin-1 (ET-1) were measured respectively. After treatment

all parameters in the 24-h ABPM and the elasticity of the carotid artery (β

AC and PVWβ) were markedly improved

the level of NO was increased

and ET-1 was decreased in both groups as compared with values before treatment (P<0.05 or P<0.01). Further

the improvements in the ratio of T/P of SBP & DBP and in the level of NO and ET-1 in the treatment group were more signifificant than those in the control group (P<0.05). There were no signifificant differences in all parameters in the ABPM monitoring and the elasticity of the carotid artery

the recovery of blood pressure circadian rhythm

and the therapeutic effect of antihypertension in EH patients between the two groups (P>0.05). Chinese herbal medicine for CGSHY may lower the blood pressure smoothly and recover the circadian rhythm of blood pressure in EH patients. They may also improve the carotid elasticity of EH patients similar to that of Enalapril. The mechanism of action of Chinese herbs on EH might be related to the regulation of vascular endothelium function.

Abstract

To observe the effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang (平肝潜阳

CGSHY) on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension (EH). Adopting a parallel

randomized design

sixty-four patients with EH of stages I and II were randomly divided into two groups according to a random number table

including stiffness parameter (β)

pressure-strain elastic modulus (Ep)

arterial compliance (AC)

augmentation index (AI)

and pulse wave velocity (PVWβ) were determined by the echo-tracking technique before and after a 12-week treatment. In the meantime

their levels of nitric oxide (NO) and endothelin-1 (ET-1) were measured respectively. After treatment

all parameters in the 24-h ABPM and the elasticity of the carotid artery (β

AC and PVWβ) were markedly improved

the level of NO was increased

and ET-1 was decreased in both groups as compared with values before treatment (P<0.05 or P<0.01). Further

the recovery of blood pressure circadian rhythm

关键词

Essential Hypertensioncircadian rhythm of blood pressureChinese herbal medicine for calming Gan and suppressing hyperactive yangartery elasticity function

Keywords

Essential Hypertensioncircadian rhythm of blood pressureChinese herbal medicine for calming Gan and suppressing hyperactive yangartery elasticity function

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