Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model

Zhong-wen Xue; Xiao-ming Shang; Song-hui Lv; Hong Xu; Qi Zhang; Chen Wang

doi:10.1007/s11655-013-1457-z

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Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model

Updated：2021-08-27

- Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model
- Chinese Journal of Integrative Medicine Vol. 19, Issue 5, Pages: 347-352(2013)
- Affiliations：
  
  1. Department of Internal Medicine, Hebei Medical University,Hebei Province,Shijiazhuang,China
  2. Department of Obstetrics, Beijing Fangshan District Maternal and Child Health Hospital,Beijing,China
  3. Medical Research Center, Hebei United University,Hebei Province,Tangshan,China
  4. Department of Cardiology, the Tangshan Worker’s Hospital of Hebei Medical University,Hebei Province,Tangshan,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1457-z
  CLC：
- Published：2013，
  
  Published Online：15 May 2013，
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Xue, Zw., Shang, Xm., Lv, Sh. et al. Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model., Chin. J. Integr. Med. 19, 347–352 (2013). https://doi.org/10.1007/s11655-013-1457-z

Zhong-wen Xue, Xiao-ming Shang, Song-hui Lv, et al. Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model. [J]. Chinese Journal of Integrative Medicine 19(5):347-352(2013)
Xue, Zw., Shang, Xm., Lv, Sh. et al. Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model., Chin. J. Integr. Med. 19, 347–352 (2013). https://doi.org/10.1007/s11655-013-1457-z DOI：

Zhong-wen Xue, Xiao-ming Shang, Song-hui Lv, et al. Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model. [J]. Chinese Journal of Integrative Medicine 19(5):347-352(2013) DOI： 10.1007/s11655-013-1457-z.

摘要

To investigate the effect of Shenshao Decoction (参芍汤) on the inflammatory status: in the aorta in a rat model of atherosclerosis. Forty Sprague-Dawley rats were randomly divided into: five groups

8 rats in each group: control untreated group

atherosclerosis group

atherosclerosis with Shenshao Decoction (low dose) group

atherosclerosis with Shenshao Decoction (high dose) group

atherosclerosis with simvastatin group. To stimulate atherosclerosis

the rats were fed vitamin D3 and a high-cholesterol diet. Four weeks later

treatments were maintained for eight weeks. Morphology changes were investigated by hematoxylin and eosin staining. Serum levels of total cholesterol (TC)

triglycerides (TG)

and low-density lipoprotein cholesterol (LDL-C) were obtained by enzymatic assays with use of an automated biochemical analyzer. The expression of malondialdehyde (MDA)

glutathione peroxidase (GSH-PX) were detected by enzyme-enzymelinked immunosorbent assay. The expression levels of interleukin (IL)-1β

IL-17A

and IL-23 were detected by linked immunoblotting. Shenshao Decoction treatment decreased TC

LDL-C and MDA and increased: GSH-PX levels (P<0.01). Compared with the control group

IL-1β

IL-17A

and IL-23 were lower in the high and <low dose Shenshao Decoction groups and the simvastatin group (P<0.01). Shenshao Decoction: could attenuate the progression of aortal atherosclerotic plaques by inhibiting the inflammatory response in a rat atherosclerotic model.

Abstract

8 rats in each group: control untreated group

atherosclerosis group

atherosclerosis with Shenshao Decoction (low dose) group

atherosclerosis with Shenshao Decoction (high dose) group

atherosclerosis with simvastatin group. To stimulate atherosclerosis

the rats were fed vitamin D3 and a high-cholesterol diet. Four weeks later

treatments were maintained for eight weeks. Morphology changes were investigated by hematoxylin and eosin staining. Serum levels of total cholesterol (TC)

triglycerides (TG)

and low-density lipoprotein cholesterol (LDL-C) were obtained by enzymatic assays with use of an automated biochemical analyzer. The expression of malondialdehyde (MDA)

glutathione peroxidase (GSH-PX) were detected by enzyme-enzymelinked immunosorbent assay. The expression levels of interleukin (IL)-1β

IL-17A

and IL-23 were detected by linked immunoblotting. Shenshao Decoction treatment decreased TC

LDL-C and MDA and increased: GSH-PX levels (P<0.01). Compared with the control group

IL-1β

IL-17A

关键词

Shenshao Decoctionatherosclerosismalondialdehydeglutathione peroxidase

Keywords

Shenshao Decoctionatherosclerosismalondialdehydeglutathione peroxidase

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Zhujiang Hospital, Southern Medical University

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