Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model

Chun-hay Ko; Chi-man Koon; Siu-lung Yu; Kwok-ying Lee; Clara Bik-san Lau; Edwin Ho-yin Chan; Yun-kwok Wing; Kwok-pui Fung; Ping-chung Leung

doi:10.1007/s11655-014-1625-1

Your Location：

Home >

Browse articles >

Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model

Updated：2021-08-27

- Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model
- Chinese Journal of Integrative Medicine Vol. 22, Issue 5, Pages: 335-343(2016)
- Affiliations：
  
  1. Institute of Chinese Medicine, The Chinese University of Hong Kong,Hong Kong SAR,China
  2. State Key Laboratory of Photochemistry and Plant Resources in West China, The Chinese University of Hong Kong,Hong Kong SAR,China
  3. School of Life Sciences, The Chinese University of Hong Kong,Hong Kong SAR,China
  4. Department of Psychiatry, The Chinese University of Hong Kong,Hong Kong,China
  5. School of Biomedical Sciences, The Chinese University of Hong Kong,Hong Kong SAR,China
- Author bio：
- Funds：
  
  Supported by Research Fund for Innovation and Technology Support Programme (No. GHP/037/05), Innovation and Technology Commission, Hong Kong SAR, China;These authors contributed equally to this work
- DOI：10.1007/s11655-014-1625-1
  CLC：
- Published：2016，
  
  Published Online：26 August 2014，
Scan for full text
Ko, Ch., Koon, Cm., Yu, Sl. et al. Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model., Chin. J. Integr. Med. 22, 335–343 (2016). https://doi.org/10.1007/s11655-014-1625-1

Chun-hay Ko, Chi-man Koon, Siu-lung Yu, et al. Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model. [J]. Chinese Journal of Integrative Medicine 22(5):335-343(2016)
Ko, Ch., Koon, Cm., Yu, Sl. et al. Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model., Chin. J. Integr. Med. 22, 335–343 (2016). https://doi.org/10.1007/s11655-014-1625-1 DOI：

Chun-hay Ko, Chi-man Koon, Siu-lung Yu, et al. Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model. [J]. Chinese Journal of Integrative Medicine 22(5):335-343(2016) DOI： 10.1007/s11655-014-1625-1.

摘要

To assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF) extract using caffeine-induced insomnia Drosophila model and short-sleep mutants. Caffeineinduced insomnia wild-type Drosophila and short-sleep mutant flies minisleep (mns) and HyperkineticY (HkY) were used to assess the hypnotic effects of the AIF in vivo. The night time activity

the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system. Sleep was defined as any period of uninterrupted behavioral immobility (0 count per minute) lasting > 5 min. Night time sleep was calculated by summing up the sleep time in the dark period. Number of sleep bouts was calculated by counting the number of sleep episodes in the dark period. AIF at the dosage of 50 mg/mL

effectively attenuated caffeine-induced wakefulness (P<0.01) in wild-type Canton-S flies as indicated by the reduction of the sleep bouts

night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep HkY mutant flies (P<0.01). However

AIF did not produce similar effect in mns mutants. AIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel

but not rescuing the abnormal nerve firing caused by Shaker gene mutation. This study provides the scientific evidence to support the use of AIF in Chinese medicine for promoting sleep quality in insomnia.

Abstract

effectively attenuated caffeine-induced wakefulness (P<0.01) in wild-type Canton-S flies as indicated by the reduction of the sleep bouts

night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep HkY mutant flies (P<0.01). However

AIF did not produce similar effect in mns mutants. AIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel

关键词

caffeinehypnotic effectsZiziphus jujubePolygonum multiflorumPoria CocosTriticum aestivuAnemarrhena asphodeloidesPolygala tenuifoliaChinese Medicine

Keywords

caffeinehypnotic effectsZiziphus jujubePolygonum multiflorumPoria CocosTriticum aestivuAnemarrhena asphodeloidesPolygala tenuifoliaChinese Medicine

references

Li RH, Wing YK, Ho SC, Fong SY. Gender differences in insomnia—A study in the Hong Kong Chinese population. J Psychosom Res 2002;53:601–609.

Zhang J, Lam SP, Li SX, Li AM, Lai KY, Wing YK. Longitudinal course and outcome of chronic insomnia in Hong Kong Chinese children: a 5-year follow-up study of a community-based cohort. Sleep 2011;34:1395–1402.

Mahowald MW, Schenck CH. Insights from studying human sleep disorders. Nature 2005;437:1279–1285.

National Institutes of Health. National Institutes of Health State of the Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults. Sleep 2005;28:1049-1057.

Zhang J, Li AM, Kong AP, Lai KY, Tang NL, Wing YK. A community-based study of insomnia in Hong Kong Chinese children: prevalence, risk factors and familial aggregation. Sleep Med 2009;10:1040–1046.

Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med 2007;3(5 Suppl):S7–S10.

Sateia MJ, Doghramji K, Hauri PJ, Morin CM. Evaluation of chronic insomnia. An American Academy of Sleep Medicine review. Sleep 2000;23:243–308.

Morin CM, Gramling SE. Sleep patterns and aging: comparison of older adults with and without insomnia complaints. Psychol Aging 1989;4:290–294.

Bonnet MH, Arand DL. Hyperarousal and insomnia: state of the science. Sleep Med Rev 2010;14:9–15.

Erman MK. Therapeutic options in the treatment of insomnia. J Clin Psychiatry 2005;66(Suppl)9:18–23.

Lam SP, Fong SY, Ho CK, Yu MW, Wing YK. Parasomnia among psychiatric outpatients: a clinical, epidemiologic, cross-sectional study. J Clin Psychiatry 2008;9:1374–1382.

Wing YK. Herbal treatment of insomnia. Hong Kong Med J 2001;7:392–402.

Flaws R, ed. Curing insomnia naturally with Chinese medicine. 1st ed. Boulder, Colorado, SA: Blue Poppy Press; 1997:67–80.

Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China. Beijing: People's Medical Publishing House; 2010.

Huber R, Hill SL, Holladay C, Biesiadecki M, Tononi G, Cirelli C. Sleep homeostasis in Drosophila melanogaster. Sleep 2004;27:628–639.

Shaw PJ, Cirelli C, Greenspan RJ, Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science 2000;287:1834–1837.

Kawahara M, Kagiyama H, Kanazawa Y, Tsuchiya H, Tomita K, Yokogawa K, et al. Rapid determination method of caffeine and application to monitoring of caffeine-assisted chemotherapy. Biopharm Drug Dispos 2004;25:61–67.

Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, et al. Reduced sleep in Drosophila Shaker mutants. Nature 2005;434:1087–1092.

Bushey D, Huber R, Tononi G, Cirelli C. Drosophila hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci 2007;27:5384–5393.

Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, Sehgal A, et al. Rest in Drosophila is a sleep-like state. Neuron 2000;25:129–138.

Cirelli C. The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci 2009;10:549–560.

Manev H, Dimitrijevic N, Dzitoyeva S. Techniques: fruit flies as models for neuropharmacological research. Trends Pharmacol Sci 2003;24:41–43.

Stern M, Ganetzky B. Altered synaptic transmission in Drosophila hyperkinetic mutants. J Neurogenet 1989;5:215–228.

Josephs KA, Silber MH, Fealey RD, Nippoldt TB, Auger RG, Vernino S. Neurophysiologic studies in Morvan syndrome. J Clin Neurophysiol 2004;21:440–445.

Chouinard SW, Wilson GF, Schlimgen AK, Ganetzky B. A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A 1995;92:6763–6767.

Ueda A, Wu CF. Effects of hyperkinetic, a beta subunit of Shaker voltage-dependent K+ channels, on the oxidation state of presynaptic nerve terminals. J Neurogenet 2008;22:1–13.

Paterson LM, Wilson SJ, Nutt DJ, Hutson PH, Ivarsson M. Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption. J Psychopharmacol 2009;23:475–486.

FULL TEXT LINK

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of Poria cocos hydroethanolic extract on treating adriamycin-induced rat model of nephrotic syndrome

Future view and development of immunology: Exploring the immunology based on Chinese medicine and culture

Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients

Objective tongue inspection on 142 liver cancer patients with damp-heat syndrome

Effect of Ermiao Recipe (二妙方) with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats

Related Author

No data

Related Institution

Provincial and the Ministry of Education Key Laboratory of Resource Science and Chinese Herbal Compound in Chinese Medicine, Hubei University of Chinese Medicine

Pharmacy Faculty, Hubei University of Chinese Medicine

Georg-August-Universität Göttingen, Göttingen

The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics’ Ministry of Public Health

Medical Informatics Center, Peking University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰