FOLLOWUS
Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India
- Chinese Journal of Integrative Medicine Vol. 21, Issue 4, Pages: 274-285(2015)
- Affiliations：
1. Department of Biotechnology, College of Engineering and Technology, Biju Patnaik University of Technology,Bhubaneswar,India
2. School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea
- Author bio：
- Funds：
DOI：10.1007/s11655-014-1854-y
CLC：Published：2015，
Published Online：24 September 2014，
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Patra, J.K., Das, S.K. & Thatoi, H. Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India., Chin. J. Integr. Med. 21, 274–285 (2015). https://doi.org/10.1007/s11655-014-1854-y
Jayanta Kumar Patra, Swagat Kumar Das, Hrudayanath Thatoi. Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India. [J]. Chinese Journal of Integrative Medicine 21(4):274-285(2015)
Patra, J.K., Das, S.K. & Thatoi, H. Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India., Chin. J. Integr. Med. 21, 274–285 (2015). https://doi.org/10.1007/s11655-014-1854-y DOI：
Jayanta Kumar Patra, Swagat Kumar Das, Hrudayanath Thatoi. Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India. [J]. Chinese Journal of Integrative Medicine 21(4):274-285(2015) DOI： 10.1007/s11655-014-1854-y.
摘要
To test the antioxidant
antidiabetic
anticancer and antibacterial activities along with phytochemicals of Sonneratia apetala Buch.-Ham. The antibacterial activity was determined by agar well diffusion method. The antioxidant activity was determined by standard assay. The antidiabetic activity was evaluated by α-glucosidase inhibition assay and in vivo anticancer property was determined against Ehrlich ascites carcinoma (EAC) cells in Swiss Albino mice. Further partial characterization of the methanol extracts was carried out by thin layer chromatography
high performance liquid chromatography
1H nuclear magnetic resonance spectroscopy and Fourier transform-infra red spectrum spectral analysis. Four solvent extracts (acetone
ethanol
methanol and aqueous) of leaf and bark possess strong antioxidant properties. In vivo anticancer activity of methanol extract leaf indicated positive activity showing 34% inhibition against EAC cells in Swiss Albino mice. All extracts exhibited α-glucosidase inhibitory activity in a dose-dependent manner indicating presence of promising antidiabetic properties. The extracts possess strong antibacterial activity against the selected pathogenic bacteria (minimal inhibitory concentration ranging from 1.25–5.00 mg/mL). The partial characterization of the methanol extracts of leaf and bark revealed the presence of phenolics as the lead compound responsible for studied bioactivities of the plant extracts. Sonneratia apetala extracts have potent antibacterial
antioxidant
antidiabetic and anticancer properties which can be further exploited for its pharmaceutical applications.
Abstract
To test the antioxidant
antidiabetic
anticancer and antibacterial activities along with phytochemicals of Sonneratia apetala Buch.-Ham. The antibacterial activity was determined by agar well diffusion method. The antioxidant activity was determined by standard assay. The antidiabetic activity was evaluated by α-glucosidase inhibition assay and in vivo anticancer property was determined against Ehrlich ascites carcinoma (EAC) cells in Swiss Albino mice. Further partial characterization of the methanol extracts was carried out by thin layer chromatography
high performance liquid chromatography
1H nuclear magnetic resonance spectroscopy and Fourier transform-infra red spectrum spectral analysis. Four solvent extracts (acetone
ethanol
methanol and aqueous) of leaf and bark possess strong antioxidant properties. In vivo anticancer activity of methanol extract leaf indicated positive activity showing 34% inhibition against EAC cells in Swiss Albino mice. All extracts exhibited α-glucosidase inhibitory activity in a dose-dependent manner indicating presence of promising antidiabetic properties. The extracts possess strong antibacterial activity against the selected pathogenic bacteria (minimal inhibitory concentration ranging from 1.25–5.00 mg/mL). The partial characterization of the methanol extracts of leaf and bark revealed the presence of phenolics as the lead compound responsible for studied bioactivities of the plant extracts. Sonneratia apetala extracts have potent antibacterial
antioxidant
antidiabetic and anticancer properties which can be further exploited for its pharmaceutical applications.
关键词
bioactive compoundschromatographyEhrlich ascites carcinomamangroveSonneratia apetala
Keywords
bioactive compoundschromatographyEhrlich ascites carcinomamangroveSonneratia apetala
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