Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study

Jie Liu; Hong-sheng Lin; Wei Hou; Bao-jin Hua; Pei-tong Zhang; Jie Li; Shen-yu Wang; Ying Xie; Yue Zhang; Guang-ru Xie; Mei-ying Zhang; Wen-guang Shi; Nian-bo Guan; Tian-yu Guan; Cong-huang Li; Li-yuan Lu; Ying Zhang; Dao-rui Li; Hao Liu

doi:10.1007/s11655-016-2737-1

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Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study

Updated：2021-08-27

- Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study
- Chinese Journal of Integrative Medicine Vol. 23, Issue 10, Pages: 733-739(2017)
- Affiliations：
  
  1. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Integrative Oncology, Liaoning Cancer Hospital,Shenyang,China
  3. Department of Traditional Chinese Medicine, Shanxi Cancer Hospital,Xi’an,China
  4. Traditional Chinese Medicine Department, Jilin Cancer Hospital,Changchun,China
  5. Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital,Tianjin,China
- Author bio：
- Funds：
  
  Supported by National Key Technologies Research and Development Program for the 11th Five-Year Plan (No. 2006BAI04A05)
- DOI：10.1007/s11655-016-2737-1
  CLC：
- Published：2017，
  
  Published Online：28 October 2016，
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Liu, J., Lin, Hs., Hou, W. et al. Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study., Chin. J. Integr. Med. 23, 733–739 (2017). https://doi.org/10.1007/s11655-016-2737-1

Jie Liu, Hong-sheng Lin, Wei Hou, et al. Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study. [J]. Chinese Journal of Integrative Medicine 23(10):733-739(2017)
Liu, J., Lin, Hs., Hou, W. et al. Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study., Chin. J. Integr. Med. 23, 733–739 (2017). https://doi.org/10.1007/s11655-016-2737-1 DOI：

Jie Liu, Hong-sheng Lin, Wei Hou, et al. Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study. [J]. Chinese Journal of Integrative Medicine 23(10):733-739(2017) DOI： 10.1007/s11655-016-2737-1.

摘要

To determine whether additional Chinese medicine (CM) could prolong survival and improve the quality of life (QOL) in patients with advanced non-small cell lung cancer (NSCLC) compared with Western medicine (WM) alone. This was a multicenter

prospective cohort study. A total of 474 hospitalized patients with stage III–IV NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy

chemotherapy

and optimal supportive therapy according to the National Comprehensive Cancer Network (NCCN) guidelines. In the integrative medicine (IM) group

individualized CM (Chinese patent medicines and injections) and WM were administered. The primary end point was overall survival

and the secondary end points were time to disease progression

adverse events

and QOL. Follow-up clinical examinations and chest radiography were performed every 2 months. The median survival was 16.60 months in the IM group and 13.13 months in the WM group (P<0.01). The incidences of loss of appetite

nausea

and vomiting in the IM group were significantly lower than those in the WM group (P<0.05). The QOL based on Functional Assessment of Cancer Therapy-Lung in the IM group was markedly higher than that in the WM group at the fourth course (P<0.05). Additional CM may prolong survival and improve the QOL patients with NSCLC. The adverse effects of radio- and chemotherapy may be attenuated as CM is used in combination with conventional treatments.

Abstract

prospective cohort study. A total of 474 hospitalized patients with stage III–IV NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy

chemotherapy

and optimal supportive therapy according to the National Comprehensive Cancer Network (NCCN) guidelines. In the integrative medicine (IM) group

individualized CM (Chinese patent medicines and injections) and WM were administered. The primary end point was overall survival

and the secondary end points were time to disease progression

adverse events

nausea

关键词

advanced non-small cell lung cancerChinese MedicineIntegrative Medicine

Keywords

advanced non-small cell lung cancerChinese MedicineIntegrative Medicine

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