Ya-jun XUE, Ying XIE, Guo-liang ZHAO, et al. Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 26(8):617-623(2020)
DOI:
Ya-jun XUE, Ying XIE, Guo-liang ZHAO, et al. Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 26(8):617-623(2020) DOI: 10.1007/s11655-019-2702-x.
Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
摘要
Abstract
Objective:
2
To evaluate the effectiveness and safety of oral Chinese herbal medicines (CHMs) on post-percutaneous coronary intervention (PCI) patients with depressive disorder in coronary heart disease (CHD).
Methods:
2
A literature search was conducted through databases including PubMed
Cochrane Library
Chinese National Knowledge Infrastructure Databases (CNKI)
Chinese Biomedical Literature Database (SinoMed)
Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and Wanfang Database up to August 2018. Randomized controlled trials (RCTs) comparing CHMs with placebo or no additional treatments on the basis of standard conventional pharmacological therapies were included. Data extraction
analyses and quality assessment were performed according to the Cochrane standards. RevMan 5.3 software was used to synthesize the results.
Results:
2
A total of 16 RCTs enrolling 1
443 participants were included in this systematic review. When compared with antidepressants alone
CHMs showed similar benefits with less side effects [risk ratio=0.54
95% confidence interval (CI) 0.43 to 0.69
582 patients]; meanwhile
the combination therapy may have more advantages than antidepressants alone [mean difference (MD)=–1.03
95%CI –1.81 to –0.25
267 patients). When identified with placebo
CHMs seem to have more advantages in relieving depressive symptoms (MD=–19.00
95%CI –20.02 to –17.98
189 patients). However
when compared with basic treatment of post-PCI
CHMs showed different results in two trials. In terms of post-PCI related clinical symptoms
CHMs seem to have more advantages in relieving chest pain and other general clinical symptoms. However
the heterogeneity in this review was generally high
it may be caused by different interventions used in each trial and the low quality of the trials.
Conclusions:
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In total
CHMs showed potentially beneficial effects on depressive symptoms and post-PCI related clinical symptoms. However
because of small sample size and potential bias of most trials
this result should be interpreted with caution. More rigorous trials with larger sample size and higher quality are warranted to give high quality of evidence to support the use of CHMs for CHD complicated with depression.
关键词
Keywords
Chinese herbal medicinepost-percutaneous coronary intervention patientsmeta-analysissystematic review
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Related Author
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