Colorectal cancer (CRC) is a global health challenge necessitating innovative therapeutic strategies. There is an increasing trend toward the clinical application of integrative Chinese medicine (CM) and Western medicine approaches. Chinese herbal monomers and formulations exert enhanced antitumor effects by modulating multiple signaling pathways in tumor cells

including inhibiting cell proliferation

inducing apoptosis

suppressing angiogenesis

reversing multidrug resistance

inhibiting metastasis

and regulating immunity. The synergistic effects of CM with chemotherapy

targeted therapy

immunotherapy

and nanovectors provide a comprehensive framework for CRC treatment. CM can mitigate drug toxicity

improve immune function

control tumor progression

alleviate clinical symptoms

and improve patients' survival and quality of life. This review summarizes the key mechanisms and therapeutic strategies of CM in CRC

highlighting its clinical significance. The potential for CM and combination with conventional treatment modalities is emphasized

providing valuable insights for future research and clinical practice.