Objective: Exploring the relationship between Liver-Blood Stasis (LBS) and liver fibrosis (LF) to lay a theoretical foundation of rational using traditional Chinese medicine against LF.Methods: Human procollagen peptide III (hPIIIP)

hyaluronic acid (HA)

laminin in the sera of 35 patients with hepatopathy and blood stasis syndrome (HP-BS) and 35 patients with hepatopathy and non-blood stasis syndrome (HP-NBS) were measured by radioimmunoassay. Thirty healthy subjects were taken as control. Correlation analysis between the degrees of LBS and those of the serum indexes of LF was made.Results: (1)hPIII P

HA

laminin in the sera of the patients with HP-BS were markedly higher than those in the sera of the patients with HP-NBS

but the latter were markedly higher than healthy subjects. (2) Degrees of LBS correlated closely with those of LF. (3) Xuefu Zhuyu Decoction not only might improve the degrees of LBS but also decline the serum LF indexes. Nevertheless

the curative effects in early period of taking the herbs only showed serum HA dropped.Conclusions: The nature of LF in traditional Chinese medicine is mainly LBS

the degrees of which might reflect those of LF to a certain extent. Xuefu Zhuyu Decoction showed effective in reducing serum LF indexes but it needs at least 2 months.