Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine

Liu Shan-xi; Jiang Lin; Liang Xin; Kong Wei-wei; Chen Jing; Liu Yi-guo; He Le-qin

doi:10.1007/s11655-007-0301-8

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Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine

OriginalPaper | Updated：2021-08-27

- Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine
- Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine
- 中国结合医学杂志（英文版） 2007年13卷第4期页码：301-305
- Affiliations：
  
  Institute of Hematopathy, Shanxi Medical University,Xi’an,China
- Author bio：
- Funds：
  
  Supported by the National Project for Prevention and Treatment of Hemophilia
- DOI：10.1007/s11655-007-0301-8
  中图分类号：
- 纸质出版日期：2007，
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Liu, Sx., Jiang, L., Liang, X. et al. Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine., Chin. J. Integr. Med. 13, 301–305 (2007). https://doi.org/10.1007/s11655-007-0301-8

Liu Shan-xi, Jiang Lin, Liang Xin, et al. Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine[J]. Chinese Journal of Integrative Medicine, 2007,13(4):301-305.
Liu, Sx., Jiang, L., Liang, X. et al. Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine., Chin. J. Integr. Med. 13, 301–305 (2007). https://doi.org/10.1007/s11655-007-0301-8 DOI：

Liu Shan-xi, Jiang Lin, Liang Xin, et al. Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine[J]. Chinese Journal of Integrative Medicine, 2007,13(4):301-305. DOI： 10.1007/s11655-007-0301-8.

摘要

To study the effect and safety of graded therapy featuring integrative traditional Chinese and Western medicine for the treatment of hemophilic arthritis. Forty patients with hemophilic arthritis were hospitalized randomly

with their blood coagulation factor activity determined by one-stage method and their arthritis classified into 4 stages. The treatment was applied according to the stage of arthritis and finding of intra-articular cavity puncture. For stage I

based on the principle of RICE (rest

ice

compression and elevation)

1.8 g of Xuefuda (血府达) was medicated orally once per day

intravenous dripping of 250 mL of hemostasis mixture twice a day and 1.2 g of clindamycin per day were also given for hemostasis and anti-inflammation. For stage II–III

Kangyanling (抗炎灵) was additionally administered via intra-articular cavity injection twice a week

2 mL every time

for 5–6 times in total. For stage IV

the drug for intra-articular cavity injection was replaced with 25 mg of sodium hyaluronate and the frequency of injection reduced to every two weeks

for 5–6 times in total. Coagulation factors III and IV as well as blood plasma were not given in the whole treatment course. Short-term therapeutic effects and adverse reaction in patients were evaluated

and the long-term effects were followed-up after patients left the hospital with 6-month consolidation therapy by Xuefuda. After a 3-week treatment

33 patients (82.5%) were completely remitted; 5 (12.5%) were partially remitted and 2 (5.0%) un-remitted

setting the short-term effective rate at 95.0% (38 cases). The 6-month follow-up showed that except for a relapse in 2 and 4 patients of stage III and IV respectively

long-term remission displayed in all the other 34 patients

with the remission sustaining rate being 85.0%. No complication such as an infection

bleeding or aggravating pain occurred in the 215 times intra-articular puncturing conducted in the 40 patients. Normal figures were shown in liver and kidney function

electrolytes

ECG

blood glucose and routine test of blood and urine throughout the course. The graded treatment of integrative medicine for hemophilia with non-blood preparation has a favorable effect and is safe or without any adverse reaction

which opens a high efficacy and new safe path and thinking for the treatment of and deformity prevention in the hemophilic patients.

Abstract

based on the principle of RICE (rest

ice

compression and elevation)

1.8 g of Xuefuda (血府达) was medicated orally once per day

intravenous dripping of 250 mL of hemostasis mixture twice a day and 1.2 g of clindamycin per day were also given for hemostasis and anti-inflammation. For stage II–III

Kangyanling (抗炎灵) was additionally administered via intra-articular cavity injection twice a week

2 mL every time

for 5–6 times in total. For stage IV

the drug for intra-articular cavity injection was replaced with 25 mg of sodium hyaluronate and the frequency of injection reduced to every two weeks

and the long-term effects were followed-up after patients left the hospital with 6-month consolidation therapy by Xuefuda. After a 3-week treatment

33 patients (82.5%) were completely remitted; 5 (12.5%) were partially remitted and 2 (5.0%) un-remitted

setting the short-term effective rate at 95.0% (38 cases). The 6-month follow-up showed that except for a relapse in 2 and 4 patients of stage III and IV respectively

long-term remission displayed in all the other 34 patients

with the remission sustaining rate being 85.0%. No complication such as an infection

bleeding or aggravating pain occurred in the 215 times intra-articular puncturing conducted in the 40 patients. Normal figures were shown in liver and kidney function

electrolytes

ECG

which opens a high efficacy and new safe path and thinking for the treatment of and deformity prevention in the hemophilic patients.

关键词

integrative traditional Chinese and Western medicinetreatmenthemophilic arthritiseffect

Keywords

integrative traditional Chinese and Western medicinetreatmenthemophilic arthritiseffect

references

Ye SG. Internal medicine. 6th ed. Beijing: People’s Medical Publishing House, 2004:663–666.

Arruda VR, Schuettrumpf J, Herzog RW, et al. Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype I. Blood 2004;103:85–92.

Follenzi A, Battaglia M, Lombardo A, et al. Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice. Blood 2004;103:3700–3709.

Gilles J, Grailly S, De Maeyer M, et al. In vivo neutralization of a C2 domain-specific human anti-factor VIII inhibitor by an anti-idiotypic antibody. Blood 2004;103: 2617–2623.

Zhang ZN. Standard for diagnosis and efficacy evaluation of blood disease. 2nd ed. Beijing: Science Press, 1998:304–311.

Battistella LR. Maintenance of musculoskeletal function in people with haemophilia. Haemophilia 1998;4(Suppl12):26–32.

Pettersson H, Ahberg A, Nilsson M, et al. Amdiological classification of hemophilic arthropathy. Clin Orthop 1980; 149(6):153–159.

Theiler R, Bruhlmann P. Overall tolerability and analgesic activity of intra-articular sodium hyaluronate in the treatment of knee osteoarthritis. Curr Med Res Opin 2005; 21:1727–1733.

Petrella RJ. Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience. Am J Phys Med Rehabil 2005; 84:278–283.

Shahinian H, Levine JP, Bradley JP, et al. Programmed healing of membranous bone in the fetal lamb. Ann Plast Surg 2005; 54: 79–84.

Babhulkar S, Pande K, Babhulkar S, et al. Nonunion of the diaphysis of long bones. Clin Orthop Relat Res 2005; (431): 50–56.

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