Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy

Xu-sheng Li; Wei-ying Zheng; Shi-xian Lou; Xiao-wen Lu; Shang-he Ye

doi:10.1007/s11655-009-0026-8

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Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy

OriginalPaper | Updated：2021-08-27

- Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy
- Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy
- 中国结合医学杂志（英文版） 2009年15卷第1期页码：26-29
- Affiliations：
  
  1. Medical College, Jinhua College of Profession and Technology,Jinhua,China
  2. The Affiliated Hospital of Jinhua College of Profession and Technology,Jinhua,China
- Author bio：
- Funds：
  
  Supported by the Scientific Research Grant of Zhejiang Provincial Administration Bureau of Education (No. 20051319)
- DOI：10.1007/s11655-009-0026-8
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-3-7，
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Li, Xs., Zheng, Wy., Lou, Sx. et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy., Chin. J. Integr. Med. 15, 26–29 (2009). https://doi.org/10.1007/s11655-009-0026-8

Xu-sheng Li, Wei-ying Zheng, Shi-xian Lou, et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 2009,15(1):26-29.
Li, Xs., Zheng, Wy., Lou, Sx. et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy., Chin. J. Integr. Med. 15, 26–29 (2009). https://doi.org/10.1007/s11655-009-0026-8 DOI：

Xu-sheng Li, Wei-ying Zheng, Shi-xian Lou, et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 2009,15(1):26-29. DOI： 10.1007/s11655-009-0026-8.

摘要

To explore the effect of ginkgo leaf extract (GLE) on vascular endothelial function (VEF) in patients with early stage diabetic nephropathy (DN). Sixty-four patients were randomized equally by a randomzing digital table into two groups

the treated group and the control group. They were all treated for 8 weeks with conventional therapy for diabetes

but GLE tablets were given to the treated group additionally. Changes in VEF were estimated before and after treatment by ultrasonic examination of the brachial artery. In the meantime

changes in plasma levels of the von Willebrand factor (vWF)

nitric oxide (NO) and endothelin-1 (ET-1) were observed as well. The brachial arterial endothelium dependent dilating function in the treated group increased from 4.91±2.31% before treatment to 6.78±3.89% after treatment (P<0.05)

while the level of vWF decreased from 182.05±64.13% to 128.56±48.98%

and that of NO increased from 50.16±24.64 μmol/L to 70.65±28.71 μmol/L (P<0.01). However

these indexes were not significantly changed in the control group after treatment (P>0.05). GLE could decrease the plasma level of vWF

raise the plasma NO level and improve the endothelium dependent vascular dilating function in DN patients.

Abstract

the treated group and the control group. They were all treated for 8 weeks with conventional therapy for diabetes

but GLE tablets were given to the treated group additionally. Changes in VEF were estimated before and after treatment by ultrasonic examination of the brachial artery. In the meantime

changes in plasma levels of the von Willebrand factor (vWF)

while the level of vWF decreased from 182.05±64.13% to 128.56±48.98%

and that of NO increased from 50.16±24.64 μmol/L to 70.65±28.71 μmol/L (P<0.01). However

these indexes were not significantly changed in the control group after treatment (P>0.05). GLE could decrease the plasma level of vWF

raise the plasma NO level and improve the endothelium dependent vascular dilating function in DN patients.

关键词

Ginkgo leaf extractdiabetic nephropathyendothelial functionvon Willebrand factor

Keywords

Ginkgo leaf extractdiabetic nephropathyendothelial functionvon Willebrand factor

references

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Mogensen CE. Early glomerular hyperfiltration in insulindependent diabetics and late nephropathy. Scand J Clin Lab Invest 1986;46: 201–206.

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Li XS, Wang L, Chen GR. The pharmacodynamic studies of Ginkgo Biloba extract on diabetes mellitus. J Jinhua Coll Profession Technol (Chin) 2004;4:24–26.

Wu BM, Li XS, Chen SM, Mao SZ, Chen XF, Li AL et al. Effects of ginkgo biloba extract on the content of endothelin and nitrogen monoxide in blood and testis tissue in diabetic rats. J Wenzhou Med Coll (Chin) 2006;36:333–336.

Jiang W. Effect of Ginkgo Leaf on urine endothelia levels in patients with early diabetic nephropathy. J Med Forum (Chin) 2007;28:70, 73.

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