Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

Zhi Cheng; Jia-li Wu; Jun-fa Chen

doi:10.1007/s11655-009-0063-3

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Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

OriginalPaper | Updated：2021-08-27

- Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin
- Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin
- 中国结合医学杂志（英文版） 2009年15卷第1期页码：63-65
- Affiliations：
  
  1. Department of Hematology, Hangzhou Municipal Third People’s Hospital,Hangzhou,China
  2. Department of Hematology, Zhejiang Provincial Traditional Chinese Medicine Hospital,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-009-0063-3
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-3-7，
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Cheng, Z., Wu, Jl. & Chen, Jf. Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin., Chin. J. Integr. Med. 15, 63–65 (2009). https://doi.org/10.1007/s11655-009-0063-3

Zhi Cheng, Jia-li Wu, Jun-fa Chen. Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin[J]. Chinese Journal of Integrative Medicine, 2009,15(1):63-65.
Cheng, Z., Wu, Jl. & Chen, Jf. Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin., Chin. J. Integr. Med. 15, 63–65 (2009). https://doi.org/10.1007/s11655-009-0063-3 DOI：

Zhi Cheng, Jia-li Wu, Jun-fa Chen. Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin[J]. Chinese Journal of Integrative Medicine, 2009,15(1):63-65. DOI： 10.1007/s11655-009-0063-3.

摘要

To explore the efficacy and mechanism of Yixuesheng capsule (益血生胶囊

YXS) combined with recombination human erythropoietin (RHE) in treating male neoplastic anemia (NA). Sixty-five patients were randomized into two groups

the 33 patients in the treated group treated with a combined therapy of YXS and RHE

and the 32 in the control group treated with RHE alone

all for 12 weeks. Related clinical indexes

including hemoglobin (Hgb)

red blood cell (RBC)

hematocrit (HMC)

testosterone (T)

estradiol (E2) and prolactin (PRL)

were measured before and after treatment.) After treatment

Hgb in the treated group and the control group was 108±5 g/L and 104±8 g/L respectively

showing marked improvement as compared with that before treatment (P<0.01)

and the improvement in the former was more significant than that in the latter (P<0.05). Further

the level of T was also increased in the treated group after treatment (P<0.05)

and showed a significant difference from that of the control group (P<0.05). YXS capsule combined with RHE shows a better therapeutic effect in treating NA than that of RHE alone

and the effect might be through stimulation by YXS of erythropoiesis which could promote the secretion of testosterone.

Abstract

To explore the efficacy and mechanism of Yixuesheng capsule (益血生胶囊

YXS) combined with recombination human erythropoietin (RHE) in treating male neoplastic anemia (NA). Sixty-five patients were randomized into two groups

the 33 patients in the treated group treated with a combined therapy of YXS and RHE

and the 32 in the control group treated with RHE alone

all for 12 weeks. Related clinical indexes

including hemoglobin (Hgb)

red blood cell (RBC)

hematocrit (HMC)

testosterone (T)

estradiol (E2) and prolactin (PRL)

were measured before and after treatment.) After treatment

Hgb in the treated group and the control group was 108±5 g/L and 104±8 g/L respectively

showing marked improvement as compared with that before treatment (P<0.01)

and the improvement in the former was more significant than that in the latter (P<0.05). Further

the level of T was also increased in the treated group after treatment (P<0.05)

and showed a significant difference from that of the control group (P<0.05). YXS capsule combined with RHE shows a better therapeutic effect in treating NA than that of RHE alone

and the effect might be through stimulation by YXS of erythropoiesis which could promote the secretion of testosterone.

关键词

Yixuesheng capsulerecombination human erythropoietincombined therapyTestosteroneneoplastic anemia

Keywords

Yixuesheng capsulerecombination human erythropoietincombined therapyTestosteroneneoplastic anemia

references

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Zhang HY, Meng QX, Liu J, Pang LP, Yang BQ. Study on the serum erythropoietin and testoserone in patients with anemia of cancer. Chin J Prim Med Pharm (Chin) 2004;11(3):295–296.

Zhang ZN, Shen T, ed. Standard for diagnosis and therapeutic efficacy evaIuation of hematopathy. 2nd ed. Beiiing: Publishing House of Science; 1998:1–5.

Voulgari PV, Kolios G, Papadopoulos GK, Katsaraki A, Seferiadis K, Drosos AA. Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis. Clin Immunol 1999;92:153–160.

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Gabrilove JL, Cleeland CS, Livingston RB, Sarokhan B, Winer E, Einhorn LH. Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. J Clin Oncol 2001;19:2875–2882.

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