Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats
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Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats
中国结合医学杂志(英文版)2010年16卷第3期 页码:247-251
Affiliations:
Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
Author bio:
Funds:
Supported by National Basic Research Program of China (No. 2006CB504803)
Xue, M., Zhang, L., Yang, L. et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats., Chin. J. Integr. Med. 16, 247–251 (2010). https://doi.org/10.1007/s11655-010-0247-4
Mei Xue, Lu Zhang, Lin Yang, et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats[J]. Chinese Journal of Integrative Medicine, 2010,16(3):247-251.
Xue, M., Zhang, L., Yang, L. et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats., Chin. J. Integr. Med. 16, 247–251 (2010). https://doi.org/10.1007/s11655-010-0247-4DOI:
Mei Xue, Lu Zhang, Lin Yang, et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats[J]. Chinese Journal of Integrative Medicine, 2010,16(3):247-251. DOI: 10.1007/s11655-010-0247-4.
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats
摘要
To observe the pharmaceutical effect of Chinese drugs for activating blood circulation (Xiongshao Capsule
XSC
芎芍胶囊) and for activating blood circulation and detoxification (Xiongshao Capsule and Huanglian Capsule
XSHLC
黄连胶囊) in terms of the indices of thrombosis
inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. Fifty Wistar rats were randomly divided into the sham operation group
the model group
the Simvastatin group (SG)
the activating blood circulation (ABC) group
and the activating blood circulation and detoxifying (ABCD) group
with 10 rats in each group. Simvastatin (1.8 mg/kg)
XSC (0.135 g/kg) and XSHLC (0.135 g/kg) were administered to Simvastatin
ABC and ABCD group by gastrogavage
and an equal volume of normal saline was given to the sham operation group and the model group. After 2 weeks of successive medication
the rats in the model and all drug therapy groups were made into experimental carotid artery thrombosis model. The serum levels of matrix metalloproteinases (MMP-9)
tissue inhibitors to metalloproteinase (TIMP-1)
granule membrane protein-140 (GMP-140)
tissue-type plasminogen activator (t-PA)
high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were detected with enzyme-linked immunoassay 24 h later. Compared with the model group
the levels of serum GMP-140
hs-CRP
IL-6 and MMP-9 were significantly decreased
and the level of t-PA was significantly increased in the ABC and ABCD group ( P<0.05)
while the level of serum hs-CRP in ABCD group decreased significantly compared with that in the ABC group (P<0.05). Chinese drugs both for activating blood circulation and for activating blood circulation and detoxifying have good effects on regulating indices of thrombosis
inflammatory reaction and tissue damage in experimental carotid artery thrombosis rats. The effect of activating blood circulation and detoxifying drugs on regulating the level of serum hs-CRP is superior to that of activating blood circulation drug alone.
Abstract
To observe the pharmaceutical effect of Chinese drugs for activating blood circulation (Xiongshao Capsule
XSC
芎芍胶囊) and for activating blood circulation and detoxification (Xiongshao Capsule and Huanglian Capsule
XSHLC
黄连胶囊) in terms of the indices of thrombosis
inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. Fifty Wistar rats were randomly divided into the sham operation group
the model group
the Simvastatin group (SG)
the activating blood circulation (ABC) group
and the activating blood circulation and detoxifying (ABCD) group
with 10 rats in each group. Simvastatin (1.8 mg/kg)
XSC (0.135 g/kg) and XSHLC (0.135 g/kg) were administered to Simvastatin
ABC and ABCD group by gastrogavage
and an equal volume of normal saline was given to the sham operation group and the model group. After 2 weeks of successive medication
the rats in the model and all drug therapy groups were made into experimental carotid artery thrombosis model. The serum levels of matrix metalloproteinases (MMP-9)
tissue inhibitors to metalloproteinase (TIMP-1)
granule membrane protein-140 (GMP-140)
tissue-type plasminogen activator (t-PA)
high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were detected with enzyme-linked immunoassay 24 h later. Compared with the model group
the levels of serum GMP-140
hs-CRP
IL-6 and MMP-9 were significantly decreased
and the level of t-PA was significantly increased in the ABC and ABCD group ( P<0.05)
while the level of serum hs-CRP in ABCD group decreased significantly compared with that in the ABC group (P<0.05). Chinese drugs both for activating blood circulation and for activating blood circulation and detoxifying have good effects on regulating indices of thrombosis
inflammatory reaction and tissue damage in experimental carotid artery thrombosis rats. The effect of activating blood circulation and detoxifying drugs on regulating the level of serum hs-CRP is superior to that of activating blood circulation drug alone.
关键词
activating blood circulationactivating blood circulation and detoxifyingthrombosistissue damageinflammatory reaction
Keywords
activating blood circulationactivating blood circulation and detoxifyingthrombosistissue damageinflammatory reaction
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