Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia

Yong-gang Xu; Rou Ma; Xiao-hong Yang; Xu-dong Tang; Shu-zhen Sun

doi:10.1007/s11655-010-0536-7

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Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia

OriginalPaper | Updated：2021-08-27

- Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia
- Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia
- 中国结合医学杂志（英文版） 2010年16卷第5期页码：417-421
- Affiliations：
  
  National Hematological Medical Center of Traditional Chinese Medicine, Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. China (No. 30472284) and the Capital Scientific Research Development Fund for Key Medical Program (TCM, No. Development Fund for Key Medical Program (TCM, No. I-1)
- DOI：10.1007/s11655-010-0536-7
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-9-25，
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Xu, Yg., Ma, R., Yang, Xh. et al. Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia., Chin. J. Integr. Med. 16, 417–421 (2010). https://doi.org/10.1007/s11655-010-0536-7

Yong-gang Xu, Rou Ma, Xiao-hong Yang, et al. Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia[J]. Chinese Journal of Integrative Medicine, 2010,16(5):417-421.
Xu, Yg., Ma, R., Yang, Xh. et al. Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia., Chin. J. Integr. Med. 16, 417–421 (2010). https://doi.org/10.1007/s11655-010-0536-7 DOI：

Yong-gang Xu, Rou Ma, Xiao-hong Yang, et al. Effect of Yiqi Bushen Granule (益气补肾颗粒) on the peripheral natural killer cell and γ δ T-cell in the patients with minimal residual leukemia[J]. Chinese Journal of Integrative Medicine, 2010,16(5):417-421. DOI： 10.1007/s11655-010-0536-7.

摘要

To analyze the changes in peripheral natural killer T-cells (NKT) and gammadelta T-cells (γ δ T-cell) in patients with minimal residual leukemia (MRL) before and after being treated with Yiqi Bushen Granule (益气补肾颗粒

YBG) in order to determine their significance in prognosis of the disease. Granule (益气补肾颗粒

YBG) in order to determine their significance in prognosis of the disease. Before and after treatment

the changes in 36 patients (16 males and 20 females) receiving long-term (more than 3 months) YBG therapy were analyzed using multi-parameter flow cytometry

with 34 healthy persons (19 males and 15 females) acting as controls. males and 15 females) acting as controls. The absolute value and percentage of NKT cells and γ δ T-cells were all significantly raised after treatment

for NKT cells

0.52%±0.39% to 0.83%±0.66% and 7.25±7.77 cells cell/μL to 12.86±11.99 cell/μL

for γ δ T-cells

6.08%±3.03% to 7.24%±2.78% and 83.97±48.09 cell/μL 110.53±54.12 cell/μL

respectively (P<0.05 or P<0.01). YBG could regulate the immune function and elevate the amount of NKT cells and γ δ T-cells

thus to kill or suppress the residual leukemic cell in the body

which might be one of the mechanisms of YBG in prolonging the disease-free survival in MRL patients.

Abstract

YBG) in order to determine their significance in prognosis of the disease. Granule (益气补肾颗粒

YBG) in order to determine their significance in prognosis of the disease. Before and after treatment

the changes in 36 patients (16 males and 20 females) receiving long-term (more than 3 months) YBG therapy were analyzed using multi-parameter flow cytometry

for NKT cells

0.52%±0.39% to 0.83%±0.66% and 7.25±7.77 cells cell/μL to 12.86±11.99 cell/μL

for γ δ T-cells

6.08%±3.03% to 7.24%±2.78% and 83.97±48.09 cell/μL 110.53±54.12 cell/μL

respectively (P<0.05 or P<0.01). YBG could regulate the immune function and elevate the amount of NKT cells and γ δ T-cells

thus to kill or suppress the residual leukemic cell in the body

which might be one of the mechanisms of YBG in prolonging the disease-free survival in MRL patients.

关键词

minimal residual leukemiaYiqi Bushen Granulenatural killer T-cellgamma-delta T-cell

Keywords

minimal residual leukemiaYiqi Bushen Granulenatural killer T-cellgamma-delta T-cell

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Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice