Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients

Bao-dong Ye; Xiang Zhang; Ke-ding Shao; Dan Chen; Yu Zhang; Di-jiong Wu; Qing-hong Yu; Jian-ping Shen; Yi-ping Shen; Yu-hong Zhou

doi:10.1007/s11655-014-2026-9

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Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients

OriginalPaper | Updated：2021-08-27

- Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients
- Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients
- 中国结合医学杂志（英文版） 2014年20卷第12期页码：903-909
- Affiliations：
  
  Hematology Department, The First Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by State Administration of Traditional Chinese Medicine (No. JDZX2012178), 2011 Special Research Funds for the Traditional Chinese Medicine Industry (No. 201107001) and Zhejiang Provincial Traditional Chinese Medicine Administration Bureau Program (No. 2007CA025)
- DOI：10.1007/s11655-014-2026-9
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-11-27，
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Ye, Bd., Zhang, X., Shao, Kd. et al. Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients., Chin. J. Integr. Med. 20, 903–909 (2014). https://doi.org/10.1007/s11655-014-2026-9

Bao-dong Ye, Xiang Zhang, Ke-ding Shao, et al. Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients[J]. Chinese Journal of Integrative Medicine, 2014,20(12):903-909.
Ye, Bd., Zhang, X., Shao, Kd. et al. Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients., Chin. J. Integr. Med. 20, 903–909 (2014). https://doi.org/10.1007/s11655-014-2026-9 DOI：

Bao-dong Ye, Xiang Zhang, Ke-ding Shao, et al. Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients[J]. Chinese Journal of Integrative Medicine, 2014,20(12):903-909. DOI： 10.1007/s11655-014-2026-9.

摘要

To determine the effect of combined treatment with Chinese medicine (CM) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) on patients with severe aplastic anemia (SAA). Eleven patients were treated with CM plus allo-HSCT. Nine patients received a conditioning regimen consisting of fludarabine (Flu)

anti-thymocyte globulin (pig ALG)

or anti-lymphocyte globulin (Rabbit ATG) and cyclophosphamide (CY)

and two patients received pig ALG and CY. All patients were treated with Kidney (Shen)-reinforcing

blood-activating

and stasis-removing (KBS) herbal preparation beginning at 1 week before transplantation and ending at 8 weeks after transplantation. Chimerism status was assessed by analyzing short tandem repeat (STR) polymorphisms. All patients recovered hematopoietic function and none had graft failure. The median number of days required for the absolute neutrophil count (ANC) increased to >0.5×109/L was 15 days (12–22 days) and for spontaneous platelet recovery to >20×109/L without post-transplantation transfusion was 17 days (15–27 days). Nine patients were long-term survivors and achieved full donor chimerism. The overall cumulative incidence of acute graft versus host disease (GVHD) grades I–II and III–IV was 18.2% (2/11) and 9.1% (1/11)

respectively. The overall accumulated incidence of chronic GVHD was 27.3% and all patients had limited chronic GVHD. At a median follow-up time of 32 months (range: 12–97 months)

9 patients were still alive. The estimated 5-year overall survival (OS) rate was 81.8%. The incidence of treatment-related mortality

2-year post-transplantation

was 18.2%. Two patients died from GVHD after transplantation. Treatment with the KBS formulation may reduce the rate of graft failure and treatment-related mortality and improve the rate of OS in SAA patients with allo-HSCT.

Abstract

anti-thymocyte globulin (pig ALG)

or anti-lymphocyte globulin (Rabbit ATG) and cyclophosphamide (CY)

and two patients received pig ALG and CY. All patients were treated with Kidney (Shen)-reinforcing

blood-activating

respectively. The overall accumulated incidence of chronic GVHD was 27.3% and all patients had limited chronic GVHD. At a median follow-up time of 32 months (range: 12–97 months)

9 patients were still alive. The estimated 5-year overall survival (OS) rate was 81.8%. The incidence of treatment-related mortality

2-year post-transplantation

关键词

severe aplastic anemiaallogeneicHematopoietic Stem CelltransplantationChinese Medicine

Keywords

severe aplastic anemiaallogeneicHematopoietic Stem CelltransplantationChinese Medicine

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