Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials

Yi-wen Che; Ke-yu Yao; Yu-peng Xi; Zi-jie Chen; Yong-le Li; Ning Yu; Shuang-qing Zhai

doi:10.1007/s11655-015-2047-z

Your Location：

Home >

Browse articles >

Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials

OriginalPaper | Updated：2021-08-27

- Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials
- Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials
- 中国结合医学杂志（英文版） 2016年22卷第4期页码：302-310
- Affiliations：
  
  School of Basic Medical Sciences, Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20120013110002)
- DOI：10.1007/s11655-015-2047-z
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2015-4-6，
Scan for full text
Che, Yw., Yao, Ky., Xi, Yp. et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 302–310 (2016). https://doi.org/10.1007/s11655-015-2047-z

Yi-wen Che, Ke-yu Yao, Yu-peng Xi, et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2016,22(4):302-310.
Che, Yw., Yao, Ky., Xi, Yp. et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 302–310 (2016). https://doi.org/10.1007/s11655-015-2047-z DOI：

Yi-wen Che, Ke-yu Yao, Yu-peng Xi, et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2016,22(4):302-310. DOI： 10.1007/s11655-015-2047-z.

摘要

To assess the beneficial and adverse effects of Wendan Decoction (温胆汤

WDD) for the treatment of schizophrenia. Five electronic databases were searched until May 2014

including the Chinese National Knowledge Infrastructure

the Chinese Biomedical Literature Database

the Chinese Scientist Journal Database

PubMed

and the Cochrane Central Register of Controlled Trials in the Cochrane Library. The randomized controlled trials (RCTs) testing WDD against placebo

antipsychotic drugs

or WDD combined with antipsychotic drugs against antipsychotic drugs alone were included. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. Thirteen RCTs (involving 1

174 patients) were included and the methodological quality was evaluated as generally low. The pooled results showed that WDD combined with antipsychotic drugs were more effective in clinical comprehensive effect

Positive and Negative Syndrome Scale (PANSS) scores and Brief Psychiatric Rating Scale scores compared with antipsychotic drugs alone. However

WDD had less effectiveness compared with antipsychotics in clinical comprehensive effect; and WDD was not different from antipsychotic drugs for PANSS scores. The side effects were significantly reduced in the intervention group compared with the control group. WDD appears to be effective on improving symptoms in patients with schizophrenia. However

due to poor methodological quality in the majority of the included trials

the potential benefit from WDD needs to be confirmed in rigorous trials and the design and reporting of trials should follow the international standards.

Abstract

To assess the beneficial and adverse effects of Wendan Decoction (温胆汤

WDD) for the treatment of schizophrenia. Five electronic databases were searched until May 2014

including the Chinese National Knowledge Infrastructure

the Chinese Biomedical Literature Database

the Chinese Scientist Journal Database

PubMed

and the Cochrane Central Register of Controlled Trials in the Cochrane Library. The randomized controlled trials (RCTs) testing WDD against placebo

antipsychotic drugs

or WDD combined with antipsychotic drugs against antipsychotic drugs alone were included. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. Thirteen RCTs (involving 1

Positive and Negative Syndrome Scale (PANSS) scores and Brief Psychiatric Rating Scale scores compared with antipsychotic drugs alone. However

due to poor methodological quality in the majority of the included trials

the potential benefit from WDD needs to be confirmed in rigorous trials and the design and reporting of trials should follow the international standards.

关键词

Wendan Decoctionschizophreniarandomized controlled trialsystematic review

Keywords

Wendan Decoctionschizophreniarandomized controlled trialsystematic review

references

American Psychological Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington DC: American Psychiatric Publishing;2013:100–102.

Combination and high-dose atypical antipsychotic therapy in patients with schizophrenia: systematic review. CADTH Technol Overv 2012;2:e2301.

Schultz SK, Andreasen NC. Schizophrenia. Lancet 1999;353:1425–1430.

van Os J, Kapur S. Schizophrenia. Lancet 2009;374:635–645.

World Health Organization. Mental health: new understanding, new hope. World Health Report;2001:33–34.

Shen Y. Psychiatry. Beijing: People's Medical Publishing House;2010:824–825.

Zhu JH, Sun HX, Xiong QY, Chen Q, Ma GQ, Ye HP. Effect of Wendan Decoction on contents of serum TNF-a, IL-6 and expression of Glu in hippocampus tissue in rats with schizophrenia. Chin J Exp Tradit Med Formul (Chin) 2014;20:160–164.

Rathbone J, Zhang L, Zhang MM, Xia J, Liu XH, Yang YC, et al. Chinese herbal medicine for schizophrenia: Cochrane systematic review of randomised trials. Br J Psychiatry 2007;190:379–384.

Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions, Version 5.1.0. The Cochrane Collaboration; 2009.

Higgins JPT, Green S. Corchrane reviewers' handbook 5.2.0. Review Manager (RevMan) [Computer program]; 2011.

Meng ZR. Clinical observation of Huanglian Wendan Decoction treating schizophrenia in internal harassment of phlegm-heat. J Guiyang Coll Tradit Chin Med (Chin) 1998;20:25–26.

Tan B. The clinical study on 30 cases with schizophrenia using Wendan Decoction combined with clozapine. J Tradit Chin Med (Chin) 2006;47:361–362.

Wang RC. Clinical comparative study of Wendan Decoction combined with small dose of chlorpromazine in treating schizophrenia. Med J Chin People's Health (Chin) 2008;20:1159–1176.

Chang W. The clinical study of schizophrenia using Wendan Decoction combined with chlorpromazine. J Henan Univ Chin Med (Chin) 2009;24:54–55.

Peng DY. The clinical observation on 36 patients with schizophrenia using integrative medicine. Guid J Tradit Chin Med Pharm (Chin) 2010;6:50–51.

Shi LR. Modifi ed Wendan Decoction combined with sulpiride in treatment of 39 cases of first episode schizophrenia. Henan Tradit Chin Med (Chin) 2010;30:386–387.

Ge X. The clinical observation on 112 patients with schizophrenia using integrative medicine. Med Frontier (Chin) 2012;1:112–113.

Dou NJ. Treatment of 40 patients with schizophrenia using Modified Wendan Decoction combined with risperidone. Guangming J Chin Med (Chin) 2012;27:1411–1412.

Guo YJ. Effect of Wendan Decoction in collaborative treatment of schizophrenia. China Modern Med (Chin) 2013; 20:112–113.

Li L. Clinical observation of schizophrenia treating with Wendan Decoction combined with risperidone. J Pract Med Techn (Chin) 2013;20:187–189.

Sun ZT. Analysis of the clinical effect of integrated traditional Chinese and Western medicine in treatment of schizophrenia. Asia-Pacifi c Tradit Med (Chin) 2014;10:74–75.

Shao H, Yang ZR. A randomized controlled study on Wendan Decoction combined with Western medicine in the treatment of schizophrenia. J Pract Tradit Chin Int Med (Chin) 2014;28:84–86.

Zhang GM. Clinical observation on the effect of Wendan Decoction combined with olanzapine in the treatment of schizophrenia. Med J Chin People's Health (Chin) 2014;26:23–24.

Hao W, ed. Pathergasiology. Beijing: People's Medical Publishing House; 2013.

Vickers A, Goyal N, Harland R, Rees R. Do certain countries produce only positiveresults? A systematic review of controlled trials. Contr Clin Trials 1998;19:159–166.

Chen KJ. Clinical service of Chinese medicine. Chin J Integr Med 2008;14:163–164.

Chen KJ, Li LZ. Study of traditional Chinese medicine—which is after all the right way? Chin J Integr Med 2005;11:241–242.

Chen KJ. Where are we going? Chin J Integr Med 2010;16:100–101.

Robinson N. Integrative medicine—traditional Chinese medicine, a model? Chin J Integr Med 2011;17:21–25.

Lu AP, Chen KJ. Chinese medicine pattern diagnosis could lead to innovation in medical sciences. Chin J Integr Med 2011;17:811–817.

Lu AP, Chen KJ. Integrative medicine in clinical practice: from pattern differentiation in traditional Chinese medicine to disease treatment. Chin J Integr Med 2009;15:152.

Liu MY, Chen KJ. Convergence: the tradition and the modern. Chin J Integr Med 2012;18:164–165.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials

Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis

Effectiveness of moxibustion for exercise-induced fatigue—A systematic review for randomized controlled trials

Efficacy and safety of Flos Abelmoschus manihot (Malvaceae) on type 2 diabetic nephropathy: A systematic review