中医药在新冠肺炎病理生理、并发症和合并症方面与西药相遇

Shan-shan WANG; Xian ZENG; Ya-li WANG; Dongzhi Zhuoma; Yu-fen ZHAO; Yu-zong CHEN

doi:10.1007/s11655-022-3573-0

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中医药在新冠肺炎病理生理、并发症和合并症方面与西药相遇

Original Article | Updated：2022-06-27

- 中医药在新冠肺炎病理生理、并发症和合并症方面与西药相遇
- Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology,Complications and Comorbidities
- Chinese Journal of Integrative Medicine 2022年28卷第7期页码：627-643
- Affiliations：
  
  1.Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University, Ningbo, Zhejiang Province (315211), China
  2.Department of Biological Medicines &Shanghai Engineering Research Center of Immunotherapeutics,Fudan University School of Pharmacy, Shanghai (201203),China
  3.Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, (117543),Singapore
  4.Medical College, Tibet University, Lhasa(850011), China
  5.Department of Chemical Biology, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University,Xiamen, Fujian Province (361005), China
  6.Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education), Department of Chemistry, Tsinghua University, Beijing (102206), China
- Author bio：
  
  Prof. CHEN Yu-zong, E-mail: chenyuzong@nbu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(21778042);Singapore Academic Funds(R-148-000-273-114)
- DOI：10.1007/s11655-022-3573-0
  中图分类号：
- 纸质出版日期：2022-07-01，
  
  网络出版日期：2022-05-18，
  
  录用日期：2021-05-06
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Shan-shan WANG, Xian ZENG, Ya-li WANG, 等. 中医药在新冠肺炎病理生理、并发症和合并症方面与西药相遇[J]. Chinese Journal of Integrative Medicine, 2022,28(7):627-643.

Shan-shan WANG, Xian ZENG, Ya-li WANG, et al. Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology,Complications and Comorbidities[J]. Chinese Journal of Integrative Medicine, 2022,28(7):627-643.
Shan-shan WANG, Xian ZENG, Ya-li WANG, 等. 中医药在新冠肺炎病理生理、并发症和合并症方面与西药相遇[J]. Chinese Journal of Integrative Medicine, 2022,28(7):627-643. DOI： 10.1007/s11655-022-3573-0.

Shan-shan WANG, Xian ZENG, Ya-li WANG, et al. Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology,Complications and Comorbidities[J]. Chinese Journal of Integrative Medicine, 2022,28(7):627-643. DOI： 10.1007/s11655-022-3573-0.

摘要

目的:

研究中国国家卫生健康委员会推荐的中药如何调节新冠肺炎的主要失调

特别是临床观察到的并发症和合并症.

方法:

通过聚焦于与西药相同的有效靶点

我们研究了11种国家卫健委推荐的中药在调节新冠肺炎病理生理(炎症、病毒复制)、并发症(疼痛、头痛)和合并症(高血压、肥胖、糖尿病)方面的机制. 这些中药的草药成分及其化学成分来自于中医药信息数据库 (TCM-ID) . 化学成分作用的靶标信息和经体外试验确定的活性值来自于天然产物活性及物种来源数据库 (NPASS) . 从治疗靶点数据库 (TTD) 和DrugBank数据库中搜索针对这些靶点的已批准和临床试验药物. 靶点的通路信息从京都基因与基因组百科全书 (KEGG) 和其他文献搜索中获得.

结果:

总体而言

9个中药调节了新冠肺炎靶点发现研究发现的6个靶标

8个和11个中药分别调节了用于治疗新冠肺炎主要并发症和合并症的8个和6个已批准或临床试验药物的靶点.

结论:

国家卫健委推荐的中药针对新冠肺炎主要的病理生理学、并发症和合并症的几个靶点的协调作用

在一定程度上与西药具有共同的机制.

Abstract

Objective:

To investigate how the National Health Commission of China (NHCC)-recommended Chinese medicines (CMs) modulate the major maladjustments of coronavirus disease 2019 (COVID-19)

particularly the clinically observed complications and comorbidities.

Methods:

By focusing on the potent targets in common with the conventional medicines

we investigated the mechanisms of 11 NHCC-recommended CMs in the modulation of the major COVID-19 pathophysiology (hyperinflammations

viral replication)

complications (pain

headache) and comorbidities (hypertension

obesity

diabetes). The constituent herbs of these CMs and their chemical ingredients were from the Traditional Chinese Medicine Information Database. The experimentally-determined targets and the activity values of the chemical ingredients of these CMs were from the Natural Product Activity and Species Source Database. The approved and clinical trial drugs against these targets were searched from the Therapeutic Target Database and DrugBank Database. Pathways of the targets was obtained from Kyoto Encyclopedia of Genes and Genomes and additional literature search.

Results:

Overall

9 CMs modulated 6 targets discovered by the COVID-19 target discovery studies

8 and 11 CMs modulated 8 and 6 targets of the approved or clinical trial drugs for the treatment of the major COVID-19 complications and comorbidities

respectively.

Conclusion:

The coordinated actions of each NHCC-recommended CM against a few targets of the major COVID-19 pathophysiology

complications and comorbidities

partly have common mechanisms with the conventional medicines.

关键词

Keywords

COVID-19Chinese medicinetargettherapeutic mechanismpathophysiologycomorbidity

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