中西医结合防治脑小血管病的研究进展

ZHANG Chu-tian; CHENG Hui-ling; CHEN Kai-li; ZHANG Zhong-ping; LIN Jia-qiu; XIAO Shao-jian; CAI Jing

doi:10.1007/s11655-022-3622-8

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中西医结合防治脑小血管病的研究进展

Review | Updated：2023-02-01

- 中西医结合防治脑小血管病的研究进展
- Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine
- 中国结合医学杂志（英文版） 2023年29卷第2期页码：186-191
- Affiliations：
  
  1.Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
  2.the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
- Author bio：
  
  Prof. CAI Jing, E-mail: caij1@163.com
- Funds：
  
  the National Natural Science Foundation of China(82074507;81904263);Chinese Medicine Research Project Plan of Fujian Province in 2021-2024(2021ZYJC02);Clinical Special Project of Fujian University of Traditional Chinese Medicine(XB2021038)
- DOI：10.1007/s11655-022-3622-8
  中图分类号：
- 纸质出版日期：2023-02，
  
  网络出版日期：2022-12-17，
  
  录用日期：2022-07-01
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中西医结合防治脑小血管病的研究进展[J]. 中国结合医学杂志（英文版）, 2023,29(2):186-191.

ZHANG Chu-tian, CHENG Hui-ling, CHEN Kai-li, et al. Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine[J]. Chinese Journal of Integrative Medicine, 2023,29(2):186-191.
中西医结合防治脑小血管病的研究进展[J]. 中国结合医学杂志（英文版）, 2023,29(2):186-191. DOI： 10.1007/s11655-022-3622-8.

ZHANG Chu-tian, CHENG Hui-ling, CHEN Kai-li, et al. Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine[J]. Chinese Journal of Integrative Medicine, 2023,29(2):186-191. DOI： 10.1007/s11655-022-3622-8.

摘要

脑小血管病 (Cerebral Small Vessel Disease

CSVD) 是大脑小动脉、小动脉、小静脉和毛细血管结构、功能异常导致的老年性脑病. CSVD病因复杂

疾病早期往往无症状

随着疾病发展表现为中风、认知能力下降、运动障碍、情绪异常等中枢神经疾病

以及心脏、肾脏、眼睛等器官损伤. 随着人口持续老龄化

CSVD的危害性与日俱增. 目前

不仅针对CSVD预防性治疗和无症状-轻症阶段干预措施缺乏

还亟需寻找更优秀的CSVD的筛查方法和诊断标志物. 融合了中国医学整体观念和辨证论治的思维和现代医学的理念的中西医结合医学

在CSVD的防治中有着独特的优势. 因此

在这篇综述中

我们对与CSVD诊断筛查相关的生物学标志物、超声影像学特征、发病相关基因和疾病危险因素进行了归纳. 此外

我们进一步探讨了基于中西医结合的CSVD预治策略

以期有助于本领域的研究.

Abstract

Cerebral small vessel disease (CSVD) is a senile brain lesion caused by the abnormal structure and function of arterioles

venules and capillaries in the aging brain. The etiology of CSVD is complex

and disease is often asymptomatic in its early stages. However

as CSVD develops

brain disorders may occur

such as stroke

cognitive dysfunction

dyskinesia and mood disorders

and heart

kidney

eye and systemic disorders. As the population continues to age

the burden of CSVD is increasing. Moreover

there is an urgent need for better screening methods and diagnostic markers for CSVD

in addition to preventive and asymptomatic-and mild-stage treatments. Integrative medicine (IM)

which combines the holistic concepts and syndrome differentiations of Chinese medicine with modern medical perspectives

has unique advantages for the prevention and treatment of CSVD. In this review

we summarize the biological markers

ultrasound and imaging features

disease-related genes and risk factors relevant to CSVD diagnosis and screening. Furthermore

we discuss IM-based CSVD prevention and treatment strategies to stimulate further research in this field.

关键词

脑小血管病白质高信号中西医结合血脑屏障微血管功能障碍

Keywords

cerebral small vessel diseaseintegrative medicinewhite matter lesionsblood-brain barrier

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