电针对反复移植失败患者子宫内膜血流即时效应的影响：一项随机对照试验

LAI Yuan-yuan; LIU Li-ying; WU Yong-na; HUANG Lei; ZHENG Xiao-yan; GAN Di; YU Si-yi; ZHONG Ying; LIANG Fan-rong; ZHOU Ying; YANG Jie

doi:10.1007/s11655-024-3758-9

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电针对反复移植失败患者子宫内膜血流即时效应的影响：一项随机对照试验

Original Article | Updated：2024-03-22

- 电针对反复移植失败患者子宫内膜血流即时效应的影响：一项随机对照试验
- Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial
- 中国结合医学杂志（英文版） 2024年30卷第4期页码：291-298
- Affiliations：
  
  1.Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu (610032), China
  2.Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu (610032), China
  3.Yuan TCM Wellness Pte. Ltd.(999002), Pulse TCM Singapore, Singapore
- Author bio：
  
  Prof. YANG Jie, E-mail: jenny_yang_jie@126.com
- Funds：
  
  Sichuan Outstanding Young Science Project Funding(2020JDJQ0051);the National Natural Science Foundation of China(82174517;81973966)
- DOI：10.1007/s11655-024-3758-9
  中图分类号：
- 纸质出版日期：2024-04-01，
  
  网络出版日期：2024-03-04，
  
  录用日期：2023-10-18
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电针对反复移植失败患者子宫内膜血流即时效应的影响：一项随机对照试验[J]. 中国结合医学杂志（英文版）, 2024,30(4):291-298.

LAI Yuan-yuan, LIU Li-ying, WU Yong-na, et al. Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2024,30(4):291-298.
电针对反复移植失败患者子宫内膜血流即时效应的影响：一项随机对照试验[J]. 中国结合医学杂志（英文版）, 2024,30(4):291-298. DOI： 10.1007/s11655-024-3758-9.

LAI Yuan-yuan, LIU Li-ying, WU Yong-na, et al. Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2024,30(4):291-298. DOI： 10.1007/s11655-024-3758-9.

摘要

目的:

探讨电针对反复移植失败患者子宫内膜血流即时效应的影响.

方法:

将2022年3月至2022年12月纳入的80例反复移植失败患者随机分为电针组 (40例) 和等待治疗组 (40例) . 基线期采集患者基本信息并进行第一次阴道超声检查; 治疗期

电针组采用毫针针刺神庭、百会、本神、双侧子宫、肓俞、三阴交和血海等穴

其中电针连接双侧子宫、肓俞以及三阴交和血海. 电针采用疏密波

频率4/20HZ

治疗30分钟. 等待治疗组不进行任何操作. 30分钟后两组患者立即进行第二次阴道超声检查. 测量的主要结局指标是子宫内膜血流量. 次要结局指标是双侧子宫动脉指数、子宫内膜体积、子宫内膜血流分型、子宫内膜和卵巢的血管分布指数、胚胎种植率和临床妊娠率.

结果:

电针组的双侧子宫动脉搏动指数较针刺前明显下降 (

0.05)

子宫内膜血流分型明显改善 (

0.05) . 同时

电针组的子宫内膜血流分型以及子宫内膜和右侧卵巢的血管分布指数明显高于等待治疗组 (

0.05) . 但是

两组间的子宫内膜血流量 (VI

VFI) 、子宫内膜体积、胚胎种植率和临床妊娠率没有统计学差异 (

0.05) . 此外

电针组没有相关不良反应的报告.

结论:

电针可以即时改善反复移植失败患者子宫内膜血流分型以及子宫内膜和右侧卵巢的血管分布指数. 但是未来还需要更多高质量多中心的随机对照试验来探讨电针对子宫内膜血流的长期效应及其对妊娠结局的影响.

Abstract

Objective:

To investigate the immediate effects of electro-acupuncture (EA) on endometrial blood flow among recurrent implantation failure (RIF) patients.

Methods:

Eighty RIF patients

enrolled from March 2022 to December 2022

were randomly allocated into either the EA group (40 cases) or the waiting-list (WL) group (40 cases) by using a random number table. The EA group underwent acupuncture at points of Shenting (GV 24)

Baihui (GV 4)

Benshen (GB 13)

bilateral Zigong (EX-CA 1)

Huangshu (KI 16)

Sanyinjiao (SP 6) and Xuehai (SP10)

and electric acupuncture apparatus was connected to EX-CA 1

KI 16

SP 6

and SP 10 with disperse-dense waves at 4/20 Hz frequencies for 30 min after transvaginal ultrasound

while the WL group received no intervention. The primary outcome measured was the endometrial volume blood flow. The secondary outcomes included the bilateral uterine artery index

endometrial volume

endometrial blood flow type

vascular distribution index (VI

) for endometrial and ovary

clinical pregnancy rate

and embryo implantation rate.

Results:

In the EA group

there was a notable decrease in the bilateral pulsatility index and a significant improvement in the endometrial blood flow type post-EA (

0.05). Both the endometrial blood flow type and VI

for the endometrium and right ovary were markedly higher in the EA group compared to the WL group post-treatment (

0.05). Conversely

no significant disparities were observed in vascular index

flow index

vascular blood flow index

uterine arterial blood flow indices

endometrial volume

clinical pregnancy rate and embryo implantation rate between the two groups after treatment (

0.05). Besides

no adverse events related to EA were observed.

Conclusions:

EA can promptly ameliorate VI

for the endometrial and right ovary

and endometrial blood flow type. Future randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes. (Trial registration No. ChiCTR2200057377)

关键词

Keywords

electro-acupuncturerecurrent implantation failuretransvaginal ultrasoundendometrial receptivity analysisrandomized controlled trial

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