Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application

GUO Ke-chen; WANG Zao-zao; SU Xiang-qian

doi:10.1007/s11655-024-4115-8

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Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application

Review | Updated：2026-08-04

- Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application
- Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application
- 中国结合医学杂志（英文版） 2026年32卷第7期页码：660-672
- Affiliations：
  
  1.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery Ⅳ, Peking University Cancer Hospital & Institute, Beijing (100142), China
  2.State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Surgery Ⅳ, Peking University Cancer Hospital & Institute, Beijing (100142), China
- Author bio：
  
  Prof. SU Xiang-qian, E-mail: suxiangqian@bjmu.edu.cn
- Funds：
  
  the Beijing Cancer Hospital Clinical Research Youth Fund(QNJJ2022010)
- DOI：10.1007/s11655-024-4115-8
  中图分类号：
- 录用：2024-04-10，
  
  网络首发：2024-09-27，
  
  纸质出版：2026-07
- Accepted：
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GUO Ke-chen, WANG Zao-zao, SU Xiang-qian. Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application[J]. 中国结合医学杂志（英文版）, 2026,32(7):660-672.

GUO Ke-chen, WANG Zao-zao, SU Xiang-qian. Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application[J]. Chinese Journal of Integrative Medicine, 2026, 32(7): 660-672.
GUO Ke-chen, WANG Zao-zao, SU Xiang-qian. Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application[J]. 中国结合医学杂志（英文版）, 2026,32(7):660-672. DOI： 10.1007/s11655-024-4115-8.

GUO Ke-chen, WANG Zao-zao, SU Xiang-qian. Chinese Medicine in Colorectal Cancer Treatment: From Potential Targets and Mechanisms to Clinical Application[J]. Chinese Journal of Integrative Medicine, 2026, 32(7): 660-672. DOI： 10.1007/s11655-024-4115-8.

摘要

Abstract

Colorectal cancer (CRC) is a global health challenge necessitating innovative therapeutic strategies. There is an increasing trend toward the clinical application of integrative Chinese medicine (CM) and Western medicine approaches. Chinese herbal monomers and formulations exert enhanced antitumor effects by modulating multiple signaling pathways in tumor cells

including inhibiting cell proliferation

inducing apoptosis

suppressing angiogenesis

reversing multidrug resistance

inhibiting metastasis

and regulating immunity. The synergistic effects of CM with chemotherapy

targeted therapy

immunotherapy

and nanovectors provide a comprehensive framework for CRC treatment. CM can mitigate drug toxicity

improve immune function

control tumor progression

alleviate clinical symptoms

and improve patients' survival and quality of life. This review summarizes the key mechanisms and therapeutic strategies of CM in CRC

highlighting its clinical significance. The potential for CM and combination with conventional treatment modalities is emphasized

providing valuable insights for future research and clinical practice.

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