Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

En-feng Song; Qiong Xiang; Kai-ming Ren; Jia-cai Hu; Fan Wu; Mei-fang Gong; Hong Zhang; Hui-min Bi

doi:10.1007/s11655-008-0103-7

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Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

OriginalPaper | Updated：2021-08-27

- Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout
- Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout
- 中国结合医学杂志（英文版） 2008年14卷第2期页码：103-106
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University,Wuhan,China
  2. Department of Endocrinology, People’s Hospital Affiliated to Wuhan University,Wuhan,China
- Author bio：
- Funds：
  
  Supported by Hubei Provincial Office of Science and Technology (No.2003AA302B5)
- DOI：10.1007/s11655-008-0103-7
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-8-6，
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Song, Ef., Xiang, Q., Ren, Km. et al. Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout., Chin. J. Integr. Med. 14, 103–106 (2008). https://doi.org/10.1007/s11655-008-0103-7

En-feng Song, Qiong Xiang, Kai-ming Ren, et al. Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout[J]. Chinese Journal of Integrative Medicine, 2008,14(2):103-106.
Song, Ef., Xiang, Q., Ren, Km. et al. Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout., Chin. J. Integr. Med. 14, 103–106 (2008). https://doi.org/10.1007/s11655-008-0103-7 DOI：

En-feng Song, Qiong Xiang, Kai-ming Ren, et al. Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout[J]. Chinese Journal of Integrative Medicine, 2008,14(2):103-106. DOI： 10.1007/s11655-008-0103-7.

摘要

To study the therapeutic effect of Weicao Capsule (威草胶囊

WCC) on gout. Two hundred gout patients were assigned to two groups. The treated group was treated with WCC and the control group was treated with Tongfengding Capsule (痛风定胶囊). Both groups were given the respective treatments orally 3 times a day

2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2-microglobulin (β2-M)

hemoglobin (Hb)

24 h urinary protein (24 h UP)

pH value of urine and blood uric acid (BUA) as well as kidney function were observed. After treatment

level of β2-M got lowered signifi cantly

Hb and 24 h UP

blood urea nitrogen

serum creatinine and the clearance rate of creatinine

as well as blood lipids all improved obviously in the treated group (all P<0.01)

while these parameters remained unchanged in the control group (P>0.05). The pH value of urine was improved in both groups showing an insignificant difference between them (P>0.05). BUA was decreased in both groups with a decrease to a larger extent in the treated group (P<0.01). The total effective rate was 87% in the treated group

which was superior to that in the control group (62%

P<0.05). WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M

BUA and lipids.

Abstract

To study the therapeutic effect of Weicao Capsule (威草胶囊

2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2-microglobulin (β2-M)

hemoglobin (Hb)

24 h urinary protein (24 h UP)

pH value of urine and blood uric acid (BUA) as well as kidney function were observed. After treatment

level of β2-M got lowered signifi cantly

Hb and 24 h UP

blood urea nitrogen

serum creatinine and the clearance rate of creatinine

as well as blood lipids all improved obviously in the treated group (all P<0.01)

which was superior to that in the control group (62%

P<0.05). WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M

BUA and lipids.

关键词

Weicao Capsulegoutblood β2-microglobulinuric acidRenal Function

Keywords

Weicao Capsulegoutblood β2-microglobulinuric acidRenal Function

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Huang TL, Xia MZ, Ren KM. Effects of Weicao Capsules on expression of α-smooth muscle actin and nuclear factor-κ β protein in the rat of uric-acid nephropathy. J Tradit Chin Med (Chin) 2003;44(4):297.

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