Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis

Ji Wei; Zhu Xuan-xuan; Tan Wen-feng; Lu Yan

doi:10.1007/BF02835742

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Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis

Updated：2021-08-27

- Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis
- Chinese Journal of Integrative Medicine Vol. 11, Issue 1, Pages: 15-21(2005)
- Affiliations：
  
  Rheumatism Immunity Department of The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine
- Author bio：
- Funds：
  
  Supported by Project of Science and Technology Commission Foundation of Jiangsu Province in 1998
- DOI：10.1007/BF02835742
  CLC：
- Published：2005，
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Wei, J., Xuan-xuan, Z., Wen-feng, T. et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis., Chin. J. Integr. Med. 11, 15–21 (2005). https://doi.org/10.1007/BF02835742

Ji Wei, Zhu Xuan-xuan, Tan Wen-feng, et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis. [J]. Chinese Journal of Integrative Medicine 11(1):15-21(2005)
Wei, J., Xuan-xuan, Z., Wen-feng, T. et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis., Chin. J. Integr. Med. 11, 15–21 (2005). https://doi.org/10.1007/BF02835742 DOI：

Ji Wei, Zhu Xuan-xuan, Tan Wen-feng, et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis. [J]. Chinese Journal of Integrative Medicine 11(1):15-21(2005) DOI： 10.1007/BF02835742.

摘要

Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG

and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest

low purine diet

sufficient water drinking and urine alkalization

etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won

insignificant difference (P>0.05)was shown between the two groups. However

the cure rate of the treated group was 26.7% while that of the control group was 10.0%

with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered

which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG

as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis

showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However

the compound recipe has better therapeutic effects

proving to be superior to single drugs.

Abstract

and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest

low purine diet

sufficient water drinking and urine alkalization

insignificant difference (P>0.05)was shown between the two groups. However

the cure rate of the treated group was 26.7% while that of the control group was 10.0%

with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered

which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG

the compound recipe has better therapeutic effects

proving to be superior to single drugs.

关键词

traditional Chinese medicine compoundrepeatedly attackingAcute Gouty Arthritistreatment

Keywords

traditional Chinese medicine compoundrepeatedly attackingAcute Gouty Arthritistreatment

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Zhu XX, Ji W, Zhang XP, et al. Experimental research of acute gouty arthritis treatment by Heat-type arthralgia relieving granules taken with warm water. J Chin Med Standard 2002; 3 (1): 60.

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