Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment

Wei Ling; Tan Jie

doi:10.1007/BF02835745

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Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment

Updated：2021-08-27

- Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment
- Chinese Journal of Integrative Medicine Vol. 11, Issue 1, Pages: 31-33(2005)
- Affiliations：
  
  Department of Gerontology, The Fifth Hospital Affiliated to Sun Yat-sen University,Guangdong Province
- Author bio：
- Funds：
- DOI：10.1007/BF02835745
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- Published：2005，
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Ling, W., Jie, T. Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment., Chin. J. Integr. Med. 11, 31–33 (2005). https://doi.org/10.1007/BF02835745

Wei Ling, Tan Jie. Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment. [J]. Chinese Journal of Integrative Medicine 11(1):31-33(2005)
Ling, W., Jie, T. Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment., Chin. J. Integr. Med. 11, 31–33 (2005). https://doi.org/10.1007/BF02835745 DOI：

Wei Ling, Tan Jie. Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment. [J]. Chinese Journal of Integrative Medicine 11(1):31-33(2005) DOI： 10.1007/BF02835745.

摘要

Objective: To evaluate the efficacy of Breviscapine on essential hypertension (EH) patients complicated with micro-albuminuria of renal impairment.Methods: Seventy-six EH patients were randomly assigned to the control group and the treated group

the former was given amlodipine

captopril/uropidil and the latter was given in addition Breviscapine intravenously dripped for 2 treatment courses. The indexes of serum creatinine (Cr)

blood urea nitrogen (BUN)

blood and urinary β2-microglobulin (β2-MG)

and quantitative determination of 24 hrs urinary protein were evaluated before and after treatment.Results: In the control group

compared with before treatment

the quantitative determination of 24 hrs urinary protein got reduced significantly (P<0.05)

while in the treated group

both urinary β2-MG and quantitative determination of 24 hrs urinary protein got lowered significantly (P<0.05 andP<0.01). But after treatment

compared with the control group

urinary β2-MG and quantitative determination of 24 hrs urinary protein in the treated group were obviously reduced (P<0.05).Conclusion: Besides lowering blood pressure effectively

Breviscapine could improve the renal function significantly and reduce the urinary micro-albuminuria

hence showing promising effect on renal protection.

Abstract

the former was given amlodipine

captopril/uropidil and the latter was given in addition Breviscapine intravenously dripped for 2 treatment courses. The indexes of serum creatinine (Cr)

blood urea nitrogen (BUN)

blood and urinary β2-microglobulin (β2-MG)

and quantitative determination of 24 hrs urinary protein were evaluated before and after treatment.Results: In the control group

compared with before treatment

the quantitative determination of 24 hrs urinary protein got reduced significantly (P<0.05)

while in the treated group

both urinary β2-MG and quantitative determination of 24 hrs urinary protein got lowered significantly (P<0.05 andP<0.01). But after treatment

compared with the control group

urinary β2-MG and quantitative determination of 24 hrs urinary protein in the treated group were obviously reduced (P<0.05).Conclusion: Besides lowering blood pressure effectively

Breviscapine could improve the renal function significantly and reduce the urinary micro-albuminuria

hence showing promising effect on renal protection.

关键词

BreviscapineEssential Hypertensionmicro-albuminuriarenal impairment

Keywords

BreviscapineEssential Hypertensionmicro-albuminuriarenal impairment

references

Xu DL, Ren H. Diagnosis, prevention and treatment of essential hypertension renal impairment. Chin J Cardiovasc 2004;32(2): 190–191.

Tang Z, Ji DX, Li LS. Effect of anti-hypertension treatment on rats’ chronic renal failure. J Nephr Dialys Kid Transpl 1995;8(4): 324.

Jiang XF, Qi XQ, Sun XH, et al. Clinical study on hypertension patients with early renal tubule impairment. Prac Med J 1999;15(10): 775–776.

Jia Q. The renal protective effect of angiotensin invertase inhibitor and angiotensin II receptor antagonist combined application. Chin Compreh Clin 2004;19(8): 677–678.

He MC. Clinical efficacy observation of Yunnan Breviscapine injection. Chin J Hemorheol 1999;9(3): 191–192.

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Related Institution

Institute of Integrated Traditional and Western Medicine, Xiangya Hospital, Central South University

Department of Pathology, The People’s Hospital of Xiangxi Autonomous Region, Jishou

Institute of Hypertensive Disease, Xiangya Hospital, Central South University

Department of Cardiopathy, The Second People’s Hospital of Hunan Province

Department of Echocardiography, The Third Xiangya Hospital, Central South University

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