Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats

Liu Yan-qing; Chen Gao-yang; Guo Shi-yu; Jiu Guang-zheng

doi:10.1007/BF02835749

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Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats

Updated：2021-08-27

- Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats
- Chinese Journal of Integrative Medicine Vol. 11, Issue 1, Pages: 45-48(2005)
- Affiliations：
  
  1. The Medical College of Yangzhou University,Yangzhou
  2. Zhaohe University,Japan
- Author bio：
- Funds：
  
  Supported by the Commission for Science and Technology of Jiangsu Province (No. BS96361)
- DOI：10.1007/BF02835749
  CLC：
- Published：2005，
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Yan-qing, L., Gao-yang, C., Shi-yu, G. et al. Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats., Chin. J. Integr. Med. 11, 45–48 (2005). https://doi.org/10.1007/BF02835749

Liu Yan-qing, Chen Gao-yang, Guo Shi-yu, et al. Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats. [J]. Chinese Journal of Integrative Medicine 11(1):45-48(2005)
Yan-qing, L., Gao-yang, C., Shi-yu, G. et al. Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats., Chin. J. Integr. Med. 11, 45–48 (2005). https://doi.org/10.1007/BF02835749 DOI：

Liu Yan-qing, Chen Gao-yang, Guo Shi-yu, et al. Study on the analgesic effect and mechanism of Zhitong Capsule in adjuvant arthritis rats. [J]. Chinese Journal of Integrative Medicine 11(1):45-48(2005) DOI： 10.1007/BF02835749.

摘要

Objective: To observe the analgesic effect of Zhitong Capsule (ZTC) and study its mechanism in adjuvant arthritis (AA) rats.Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups with 8 rats in each group. On the first day

except to those in the normal group that were treated with normal saline

the same amount of Freund’s complete adjuvant (FCA) was given through intradermal injection into the right hind paw to all the rats in the other groups. From the 17th day of the modeling on

the rats in groups of ZTC were administered daily through gastrogavage with a dose of 1000

500

250 mg/kg respectively

while equal volume of normal saline was given to those in the normal group and model group

and an equal volume of aspirin (ASA) solution was given to rats in the ASA group through gastrogavage for 10 days

once per day

and on the 27th day

the analgesic effect of ZTC was measured with heat withdraw method. The activities and contents of Superoxide dismutase (SOD) and lipid peroxides (LPO) in serum were observed by spectrophotometry

and the level of beta-endorphin (β-EP) in hypothalamus were determined by the assay of immunohistochemistry.Results: ZTC showed significant effects on enhancing the pain threshold and at the same time it increased the activities of SOD and reduced the contents of LPO in serum. ZTC could also increase the level of β-EP in hypothalamus.Conclusion: ZTC has analgesic effect and its mechanism is probably related with its effect in inhibiting the level of oxygen free radicals in serum and increasing the level of β-EP of hypothalamus in rats.

Abstract

except to those in the normal group that were treated with normal saline

the same amount of Freund’s complete adjuvant (FCA) was given through intradermal injection into the right hind paw to all the rats in the other groups. From the 17th day of the modeling on

the rats in groups of ZTC were administered daily through gastrogavage with a dose of 1000

500

250 mg/kg respectively

while equal volume of normal saline was given to those in the normal group and model group

and an equal volume of aspirin (ASA) solution was given to rats in the ASA group through gastrogavage for 10 days

once per day

and on the 27th day

the analgesic effect of ZTC was measured with heat withdraw method. The activities and contents of Superoxide dismutase (SOD) and lipid peroxides (LPO) in serum were observed by spectrophotometry

关键词

Zhitong CapsuleAdjuvant Arthritissuperoxide dismutaselipid peroxidesβ-endorphin

Keywords

Zhitong CapsuleAdjuvant Arthritissuperoxide dismutaselipid peroxidesβ-endorphin

references

Liu YQ, Zhu JQ, Xue YJ, et al. Experimental study of Zhitong Capsule on analgesic effect. Jiangsu J TCM 1998;19(12): 49–50.

Liu YQ, Zu JQ, Xue YJ et al. Study of Zhitong Capsule on anti-inflammatory effect. J Jiangsu Clin Med 2001; 5(1): 22–24.

Liu MP. Analgesic effect of lappaconitine on inflammatory pain. Chin Rem Clinics 2003; 3(3): 244–245.

Bao XM, Shu SY. The Stereotaxic Atlas of the rat brain. Beijing: People’s Medical Publishing House, 1991: 35–37.

Gao HM, Liu YQ, Zhu JQ. Effect of Zhitong Capsule on dysmenorrhea. J Jiangsu Clin Med 2001;5(6): 516.

Liu YQ, Zhu JQ. Clinical study of Zhitong Capsule on thirtyeight cases of occlusive injury pain. Jiangsu J TCM 2002; 23(7): 14–15.

Song BW, Wang J, Chen ZW, et al. The effect of oxygen free radicals on pain. Compilation of abstract in the first Chinese Congress of Neurology. Shanghai: the Chinese Congress of Neurology, 1995: 112.

Harbach H, Hell K, Gramsch C, et al. Beta-endorphin in the plasma of male volunteers undergoing physical exercise. Psychoneuroendocrinology 2000;25(6): 551–562.

Yan XM, editor. Clinical pain. Jilin: Yanbian People’s Press, 1996: 32–33.

Liu YQ, Zu JQ, Xue YJ, et al. Study of Compound Zhitong Capsule on analgesic effect in rats. J Jiangsu Clin Med 2000; 4(6): 455–456.

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Department of Rheumatism and Immunity, the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine

Tianjin University of Traditional Chinese Medicine

The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Department of Physiology, Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences

Medical College of Yangzhou University

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