Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs

Xiong Wu-jun; Qiu Qi-yu; Qiu De-kai

doi:10.1007/BF02835750

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Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs

Updated：2021-08-27

- Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs
- Chinese Journal of Integrative Medicine Vol. 11, Issue 1, Pages: 49-53(2005)
- Affiliations：
  
  1. Department of Gastroenterology, Shanghai East Hospital Affiliated to Tongji University,Shanghai
  2. Department of Traditional Chinese Medicine, Tongji Hospital Affiliated to Huazhong University of Science and Technology,China
  3. Shanghai Institute of Digestive Disease, Renji Hospital Affiliated to the Second Medical University of Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/BF02835750
  CLC：
- Published：2005，
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Wu-jun, X., Qi-yu, Q. & De-kai, Q. Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs., Chin. J. Integr. Med. 11, 49–53 (2005). https://doi.org/10.1007/BF02835750

Xiong Wu-jun, Qiu Qi-yu, Qiu De-kai. Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs. [J]. Chinese Journal of Integrative Medicine 11(1):49-53(2005)
Wu-jun, X., Qi-yu, Q. & De-kai, Q. Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs., Chin. J. Integr. Med. 11, 49–53 (2005). https://doi.org/10.1007/BF02835750 DOI：

Xiong Wu-jun, Qiu Qi-yu, Qiu De-kai. Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs. [J]. Chinese Journal of Integrative Medicine 11(1):49-53(2005) DOI： 10.1007/BF02835750.

摘要

Objective: To study the therapeutic effects and mechanism of Jiechangning (JCN) decoction on carrageenan induced experimental ulcerative colitis (UC).Methods: After sensitizing guinea pigs with carrageenan

we established UC animal models by free drinking water containing 2% acid degraded carrageenan (ADC). JCN decoction was orally administered once a day for 2 weeks after carrageenan treatment. Salicylazosulfapyridine (SASP) and normal saline were given to the other two groups as control. The levels of colon lipid peroxide (LPO)

acid phosphatase (ACP) activity and tumor necrosis factor-α (TNF-α) were measured; colitis activity score (CAS) was carried out for assessment of the degree of tissue inflammation and injury; the colonic pathological changes were examined simultaneously with hematoxylin and eosin (HE) and toluidine blue staining used to evaluate the therapeutic effects of JCN decoction and SASP.Results: Experimental colitis models resembling human UC were successfully induced. The levels of tissue LPO

ACP activity and the content of tissue TNF-α were markedly increased in the model group as compared with the normal control group (P<0.01) and were positively correlated with CAS. JCN decoction could reverse these changes like SASP. HE staining showed that JCN decoction and SASP could reduce CAS and the degree of tissue injury

toluidine blue staining revealed that mucosa and submucosa red metachromasia pellets in JCN group and SASP group were markedly fewer than those in the model group.Conclusion: JCN decoction is effective in treating experimental UC

which provides theoretical basis for its clinical application.

Abstract

which provides theoretical basis for its clinical application.

关键词

Jiechangning decoctionUlcerative ColitisTraditional Chinese Medicine Therapy

Keywords

Jiechangning decoctionUlcerative ColitisTraditional Chinese Medicine Therapy

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Beijing Institute of Traditional Chinese Medicine

Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University

Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Tecnology

Department of General Practice and Health Services Research, University Medical Hospital Heidelberg, Heidelberg

Beijing Zhonghui Pharmaceutical Co., Ltd.

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