Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome

Yin Guang-yao; Chen Yi; Zhang Wu-ning; Shen Xiao-jing; Jiao Jian-hua; He Xue-fen

doi:10.1007/BF02835787

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Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome

Updated：2021-08-27

- Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome
- Chinese Journal of Integrative Medicine Vol. 11, Issue 4, Pages: 264-271(2005)
- Affiliations：
  
  1. Kunshan Municipal Hospital of Traditional Chinese Medicine,Jiangsu
  2. National Center of Microanalysis, Fudan University,China
  3. The Third People’s Hospital of Wuxi City,China
- Author bio：
- Funds：
- DOI：10.1007/BF02835787
  CLC：
- Published：2005，
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Guang-yao, Y., Yi, C., Wu-ning, Z. et al. Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome., Chin. J. Integr. Med. 11, 264–271 (2005). https://doi.org/10.1007/BF02835787

Yin Guang-yao, Chen Yi, Zhang Wu-ning, et al. Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome. [J]. Chinese Journal of Integrative Medicine 11(4):264-271(2005)
Guang-yao, Y., Yi, C., Wu-ning, Z. et al. Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome., Chin. J. Integr. Med. 11, 264–271 (2005). https://doi.org/10.1007/BF02835787 DOI：

Yin Guang-yao, Chen Yi, Zhang Wu-ning, et al. Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome. [J]. Chinese Journal of Integrative Medicine 11(4):264-271(2005) DOI： 10.1007/BF02835787.

摘要

Objective: To study the physiopathologic basis of Weikangfu Granule (WKFG) in treating precancerosis of gastric mucosa in patients of chronic gastritis with Pi-deficiency syndrome (CG-PDS).Methods: One hundred and fifteen patients of CG-PDS who suffered from intestinal metaplasia (IM) and atypical hyperplasia (ATHP) of gastric mucosa

were divided into two groups. The treated group (n = 61) was treated by WKFG with its ingredients modified according to the syndrome type of patients. The control group(n= 54) was treated with Weishu granule. The histopathological and subcellular ultrastructural changes were detected by optical microscope

screening electronic microscope

transmission electronic microscope and histochemical staining; the nuclear and mitochondrial ultrastructure of gastric mucosa were analyzed with energy dispersion X-ray analyser and image analysis system. And the changes of cAMP

lipid peroxide (LPO)

Superoxide dismutase (SOD) before and after treatment in the treated group were measured and compared with those of the health control group consisting of 15 volunteers.Results: The symptomatic and pathological therapeutic effect in the treated group were significantly superior to those in the control group (P< 0.05). The contents of Zn

cAMP

SOD and3H-TdR LCT in gastric mucosa of the treated group before treatment were all lower than those of the healthy control group

yet all these indexes markedly increased after treatment

while serum LPO level

which increased before treatment was lowered after treatment. All the changes showed statistical significance (P<0.05 orP<0.01).Conclusion: WKFG can reverse IM and ATHP in patients of CG-PDS

and the effect may be realized by way of increasing the level of Zn

cAMP and SOD in gastric mucosa

promoting cell differentiation

enhancing cellular immunity and reducing oxygen free radicals and lipid peroxidation.

Abstract

screening electronic microscope

lipid peroxide (LPO)

cAMP

SOD and3H-TdR LCT in gastric mucosa of the treated group before treatment were all lower than those of the healthy control group

yet all these indexes markedly increased after treatment

while serum LPO level

which increased before treatment was lowered after treatment. All the changes showed statistical significance (P<0.05 orP<0.01).Conclusion: WKFG can reverse IM and ATHP in patients of CG-PDS

and the effect may be realized by way of increasing the level of Zn

cAMP and SOD in gastric mucosa

promoting cell differentiation

enhancing cellular immunity and reducing oxygen free radicals and lipid peroxidation.

关键词

Weikangfu GranulePi-deficiency syndromeprecancerosis of gastric mucosapathophysi-ologic basis

Keywords

Weikangfu GranulePi-deficiency syndromeprecancerosis of gastric mucosapathophysi-ologic basis

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