Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice

Zheng Miao; Liu Wen-li; Sun Han-ying; Zhou Jian-feng

doi:10.1007/BF02835790

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Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice

Updated：2021-08-27

- Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice
- Chinese Journal of Integrative Medicine Vol. 11, Issue 4, Pages: 283-286(2005)
- Affiliations：
  
  Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University,Wuhan
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 39870926)
- DOI：10.1007/BF02835790
  CLC：
- Published：2005，
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Miao, Z., Wen-li, L., Han-ying, S. et al. Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice., Chin. J. Integr. Med. 11, 283–286 (2005). https://doi.org/10.1007/BF02835790

Zheng Miao, Liu Wen-li, Sun Han-ying, et al. Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice. [J]. Chinese Journal of Integrative Medicine 11(4):283-286(2005)
Miao, Z., Wen-li, L., Han-ying, S. et al. Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice., Chin. J. Integr. Med. 11, 283–286 (2005). https://doi.org/10.1007/BF02835790 DOI：

Zheng Miao, Liu Wen-li, Sun Han-ying, et al. Study on the effects of Guiqi Oral Liquid in promoting recovery of hematopoiesis in acute irradiation injured mice. [J]. Chinese Journal of Integrative Medicine 11(4):283-286(2005) DOI： 10.1007/BF02835790.

摘要

Objective: To explore the effects and possible mechanisms of Guiqi Oral Liquid (GQOL) on the recovery of hematopoiesis in acute irradiation injured mice.Methods: The acute irradiation injured mice were randomly divided into 2 groups: the treated group and the control group

and also a normal control group was set up with 6 mice in it receiving no treatment. After the mice in the former two groups were irradiated by 6.0 Gy60Coγ-ray

every one of them was given 0. 4 ml GQOL or saline in equal volume through a gastric tube twice a day for 14 days. On the 4th

8th and 14th day after irradiation

the bone marrow mononuclear cells (BMMNC) and megakaryocytes in bone marrow tissues of the mice were counted

the proportion of hematopoietic tissues (by area) was measured

and the expression of adhesion molecules

CD44 and CD54

in bone marrow were estimated by immunochemistry. The colony forming unit of spleen (CFU-S) in the mice were counted on the 8th day after irradiation.Results: On the 4th

8th

14th day after irradiation

the count of BMMNC and megakaryocyte

and the proportion of hematopoietic tissues in the treated group were higher than those in the control group (P<0.01 orP<0.05). CD44 and CD54 expression in the treated group were higher than those in the control group on the 4th and 8th day (P<0.01)

but near normal on the 14th day (P<0.01). On the 8th day

CFU-S count in the treated group was higher than that in the control group (P<0.01).Conclusion: GQOL can regulate the expression of adhesion molecules

CD44 and CD54

in the bone marrow of the acute irradiation injured mice

which may be one of the mechanisms of GQOL in accelerating the early phase hematopoiesis recovery of mice.

Abstract

and also a normal control group was set up with 6 mice in it receiving no treatment. After the mice in the former two groups were irradiated by 6.0 Gy60Coγ-ray

every one of them was given 0. 4 ml GQOL or saline in equal volume through a gastric tube twice a day for 14 days. On the 4th

8th and 14th day after irradiation

the bone marrow mononuclear cells (BMMNC) and megakaryocytes in bone marrow tissues of the mice were counted

the proportion of hematopoietic tissues (by area) was measured

and the expression of adhesion molecules

CD44 and CD54

in bone marrow were estimated by immunochemistry. The colony forming unit of spleen (CFU-S) in the mice were counted on the 8th day after irradiation.Results: On the 4th

8th

14th day after irradiation

the count of BMMNC and megakaryocyte

but near normal on the 14th day (P<0.01). On the 8th day

CFU-S count in the treated group was higher than that in the control group (P<0.01).Conclusion: GQOL can regulate the expression of adhesion molecules

CD44 and CD54

in the bone marrow of the acute irradiation injured mice

which may be one of the mechanisms of GQOL in accelerating the early phase hematopoiesis recovery of mice.

关键词

Guiqi Oral Liquidirradiation injuryCD44CD54colony forming unit of spleen

Keywords

Guiqi Oral Liquidirradiation injuryCD44CD54colony forming unit of spleen

references

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Wu ZZ, He FC, Pei XT. Regulation and control of hematopoiesis. Shanghai: Publishing House of Shanghai Medical University, 2000: 80–87.

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Gaugler MH, Squiban C, van der Meeren A, et al. Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 1997; 72(2): 201–209.

Gaugler MH, Squiban C, Mouthon MA. Irradiation enhances the support of haematopoietic cell transmigration, proliferation and differentiation by endothelial cells. Br J Haematol 2001; 113(4): 940–950.

Chen T, Xie Y. Role of adhesion molecules in mobilization of hematopoietic cells. Chin Med J 2003; 116(2): 273–277.

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