Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension

Wang Zi-fen; Shi Shao-lan; Song Hai-xiang

doi:10.1007/BF02836352

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Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension

Updated：2021-08-27

- Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension
- Chinese Journal of Integrative Medicine Vol. 9, Issue 1, Pages: 35-38(2003)
- Affiliations：
  
  Linyi Municipal TCM Hospital, Shangdong
- Author bio：
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- DOI：10.1007/BF02836352
  CLC：
- Published：2003，
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Zi-fen, W., Shao-lan, S. & Hai-xiang, S. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension., Chin. J. Integr. Med. 9, 35–38 (2003). https://doi.org/10.1007/BF02836352

Wang Zi-fen, Shi Shao-lan, Song Hai-xiang. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension. [J]. Chinese Journal of Integrative Medicine 9(1):35-38(2003)
Zi-fen, W., Shao-lan, S. & Hai-xiang, S. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension., Chin. J. Integr. Med. 9, 35–38 (2003). https://doi.org/10.1007/BF02836352 DOI：

Wang Zi-fen, Shi Shao-lan, Song Hai-xiang. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension. [J]. Chinese Journal of Integrative Medicine 9(1):35-38(2003) DOI： 10.1007/BF02836352.

摘要

Objective:To investigate the effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension (PIH) and its mechanism.Methods: All the 92 patients accepted 75 g oral glucose tolerance test (OGTT) and insulin release test before and after treatment. These patients were divided into two groups (treated group and control group). Prepared rhubarb and nifedipine were given to the treated group

while nifedipine was given to the control group alone. Circulating endothelial cell (CEC)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) were measured and glucose area under curve (GAUC)

insulin area under curve (IAUC)

insulin sensitivity index (ISI) were calculated. And 30 normal pregnant women were selected as the healthy group.Results: CEC

TNF-α

IL-6

GAUC and IAUC of PIH patients were significantly higher than those of the normal healthy group; while ISI of PIH patients was significantly lower than that of the healthy group. ISI was significantly negatively correlated to CEC

TNF-α and IL-6. After treatment

CEC

TNF-α

IL-6

GAUC decreased and ISI increased significantly in the treated group; while in the control group

all above-mentioned parameters showed no change.Conclusion: Prepared rhubarb can improve insulin resistance of PIH by reducing vascular endothelial cell’s damage.

Abstract

while nifedipine was given to the control group alone. Circulating endothelial cell (CEC)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) were measured and glucose area under curve (GAUC)

insulin area under curve (IAUC)

insulin sensitivity index (ISI) were calculated. And 30 normal pregnant women were selected as the healthy group.Results: CEC

TNF-α

IL-6

TNF-α and IL-6. After treatment

CEC

TNF-α

IL-6

GAUC decreased and ISI increased significantly in the treated group; while in the control group

all above-mentioned parameters showed no change.Conclusion: Prepared rhubarb can improve insulin resistance of PIH by reducing vascular endothelial cell’s damage.

关键词

pregnancy complicationcardiovascularhypertensionprepared rhubarbinsulin resistance

Keywords

pregnancy complicationcardiovascularhypertensionprepared rhubarbinsulin resistance

references

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