Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats

Qiu Hong; Jin Guo-qin; Zhao Wei-kang; Zhang Xue-li

doi:10.1007/BF02836355

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Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats

Updated：2021-08-27

- Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats
- Chinese Journal of Integrative Medicine Vol. 9, Issue 1, Pages: 44-48(2003)
- Affiliations：
  
  1. Institute of Basic Medicine, Shanghai University of TCM,Shanghai
  2. The Research Institute of Gerontology of Shanghai TCM,China
- Author bio：
- Funds：
  
  This program was supported by National Natural Science Foundation of China (No. 39830450)
- DOI：10.1007/BF02836355
  CLC：
- Published：2003，
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Hong, Q., Guo-qin, J., Wei-kang, Z. et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats., Chin. J. Integr. Med. 9, 44–48 (2003). https://doi.org/10.1007/BF02836355

Qiu Hong, Jin Guo-qin, Zhao Wei-kang, et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats. [J]. Chinese Journal of Integrative Medicine 9(1):44-48(2003)
Hong, Q., Guo-qin, J., Wei-kang, Z. et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats., Chin. J. Integr. Med. 9, 44–48 (2003). https://doi.org/10.1007/BF02836355 DOI：

Qiu Hong, Jin Guo-qin, Zhao Wei-kang, et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats. [J]. Chinese Journal of Integrative Medicine 9(1):44-48(2003) DOI： 10.1007/BF02836355.

摘要

Objective: To observe the effect of Tiaoxin Recipe (TXR) on the spatial memory

brain mitochondrial energy metabolism of oxidation injured Alzheimer’s disease (AD) rats

and to explore the mechanism of TXR in treating AD.Methods: Eighty-eight SD rats were randomly divided into five groups (normal group

operative group

“AD” model group

TXR group and Aricept group). An oxygen free radical generation system (dihydroxy fumaric acid-trichloroferric-adenosine diphosphate

DHF-FeCl3-ADP) was used to create oxidation injured rat models mimic to AD; spatial learning and memory impairment (Morris water maze method)

the activity of Succinate-oxidase

NADH-oxidase

CytC-oxidase (Clark oxygen electrode method) and the expression of cytochrome oxidase (CO) II mRNA (in situ hybridization method) were observed.Results: Compared with the normal group

the spatial memory

activity of CytCoxidase and COII mRNA expression of oxidation injured “AD” rats were obviously decreased; TXR

however

could improve these functions in “AD” rat models obviously.Conclusion: The mechanism of the action of TXR in treating AD was partly related to its effect on anti-oxidation which could improve brain mitochondrial energy metabolism.

Abstract

Objective: To observe the effect of Tiaoxin Recipe (TXR) on the spatial memory

brain mitochondrial energy metabolism of oxidation injured Alzheimer’s disease (AD) rats

and to explore the mechanism of TXR in treating AD.Methods: Eighty-eight SD rats were randomly divided into five groups (normal group

operative group

“AD” model group

TXR group and Aricept group). An oxygen free radical generation system (dihydroxy fumaric acid-trichloroferric-adenosine diphosphate

DHF-FeCl3-ADP) was used to create oxidation injured rat models mimic to AD; spatial learning and memory impairment (Morris water maze method)

the activity of Succinate-oxidase

NADH-oxidase

CytC-oxidase (Clark oxygen electrode method) and the expression of cytochrome oxidase (CO) II mRNA (in situ hybridization method) were observed.Results: Compared with the normal group

the spatial memory

activity of CytCoxidase and COII mRNA expression of oxidation injured “AD” rats were obviously decreased; TXR

however

关键词

Tiaoxin Recipeoxidation injuryspatial memoryenergy metabolism

Keywords

Tiaoxin Recipeoxidation injuryspatial memoryenergy metabolism

references

LI YM, ZHANG CY, LIN SM. Theoretical exploration on Xin-benefiting and Shen-tonifying method in treating AD. J Gansu College TCM 2000;17(2): 1–3.

LIN SM. Clinical research on the effect of TXR on Alzheimer’s disease. J Shanghai Univ TCM 1997; 11(1): 44.

Morris RJ. Developments of a water-maze procedure for studying spatial learning in the rats. Neurosci Methods 1984;11: 47–60.

Zini R, Morin C, Bertelli A, et al. Effect of resveratrol on the rat brain respiratory chain. Drugs Exptl Clin Res 1999;XXV(2/3): 87–97.

Heinz S, John JL, Matthias H, et al. Liposome-mitochondrial inner membrane fusion. J Biochem 1980; 255(8): 3748–3756.

Nancy A, Simonian NA, Hyman BT, et al. Functional alterations in Alzheimer’s disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J Neuropathol Exp Neurol 1994; 53 (5): 508–512.

Meier Ruge W, Iwangoff P, Bertoni Freddari C, et al. What is primary and what is secondary for amyloid deposition in Alzheimer’s disease. Ann NY Acad Sci 1994; 719: 23–27.

Mecocci P, MacGarvey U, Kaufman AE, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993; 34: 609–616.

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