Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats

Shen Si-yu; Cai Ding-fang; Chen Wei-hua; Liu Jing; Chen Hu; Ying Jian

doi:10.1007/BF02836356

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Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats

Updated：2021-08-27

- Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats
- Chinese Journal of Integrative Medicine Vol. 9, Issue 1, Pages: 49-52(2003)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Jinling Hospital, Nanjing University,Nanjing
  2. Institute of Integrated Traditional and Western Medicine, Huashan Hospital Affiliated to Fudan University,Shanghai
- Author bio：
- Funds：
  
  Provided financial assistance by “Hundred Talented Projects” of Shanghai Health Bureau (No. 97BR016)
- DOI：10.1007/BF02836356
  CLC：
- Published：2003，
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Si-yu, S., Ding-fang, C., Wei-hua, C. et al. Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats., Chin. J. Integr. Med. 9, 49–52 (2003). https://doi.org/10.1007/BF02836356

Shen Si-yu, Cai Ding-fang, Chen Wei-hua, et al. Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats. [J]. Chinese Journal of Integrative Medicine 9(1):49-52(2003)
Si-yu, S., Ding-fang, C., Wei-hua, C. et al. Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats., Chin. J. Integr. Med. 9, 49–52 (2003). https://doi.org/10.1007/BF02836356 DOI：

Shen Si-yu, Cai Ding-fang, Chen Wei-hua, et al. Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats. [J]. Chinese Journal of Integrative Medicine 9(1):49-52(2003) DOI： 10.1007/BF02836356.

摘要

Objective: To observe and elucidate the neuroprotective effect of Xingnaojing (XNJ) injection on hippocampal N-methyl-D-aspartic acid (NMDA) receptors of focal cerebral ischemia in rats.Methods: Cerebral ischemia was established by occluding the middle cerebral artery with an intraluminal suture technique in rats. Neurological deficit score

infarct volume and quantity of NMDA receptors were estimated in all groups and compared.Results: After being treated with XNJ

the score decreased in the initial 6 hours and infarct volume decreased in 24 hours. And within 24 hours

the quantity of NMDA receptors obviously decreased compared with the model group (P<0. 01). It indicated that XNJ could ameliorate neurological behavior of middle cerebral artery occlusion rats and down-regulate the expression of hippocampal NMDA receptors.Conclusion: The neuroprotective effect of XNJ on focal cerebral ischemia is possibly related to down-regulating the expression of NMDA receptors in rats.

Abstract

infarct volume and quantity of NMDA receptors were estimated in all groups and compared.Results: After being treated with XNJ

the score decreased in the initial 6 hours and infarct volume decreased in 24 hours. And within 24 hours

关键词

Xingnaojing injectionFocal Cerebral IschemiaN-methyl-D-Aspartic acid receptorneuro-protection

Keywords

Xingnaojing injectionFocal Cerebral IschemiaN-methyl-D-Aspartic acid receptorneuro-protection

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National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College

Department of Pharmacology, Institute of Basic Medical Science, Chinese Academy of Medical Science & Peking Union Medical College

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