Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model

Zhang You-mei; Hu Ling; Tang Chun-zhi; Cao Wei

doi:10.1007/BF02836357

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Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model

Updated：2021-08-27

- Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model
- Chinese Journal of Integrative Medicine Vol. 9, Issue 1, Pages: 53-56(2003)
- Affiliations：
  
  1. Tianxin Hospital of Traditional Chinese Medicine, Tai Pei,Taiwan
  2. Piwei Institute, Guangzhou University of TCM,Guangzhou
  3. Acupunture-Massage College, Guangzhou University of TCM,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02836357
  CLC：
- Published：2003，
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You-mei, Z., Ling, H., Chun-zhi, T. et al. Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model., Chin. J. Integr. Med. 9, 53–56 (2003). https://doi.org/10.1007/BF02836357

Zhang You-mei, Hu Ling, Tang Chun-zhi, et al. Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model. [J]. Chinese Journal of Integrative Medicine 9(1):53-56(2003)
You-mei, Z., Ling, H., Chun-zhi, T. et al. Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model., Chin. J. Integr. Med. 9, 53–56 (2003). https://doi.org/10.1007/BF02836357 DOI：

Zhang You-mei, Hu Ling, Tang Chun-zhi, et al. Effect of electro-acupuncture on rat joint pathomorphology of chronic adjuvant arthritis model. [J]. Chinese Journal of Integrative Medicine 9(1):53-56(2003) DOI： 10.1007/BF02836357.

摘要

Objective:To study the effect of electro-acupuncture (EA) on pathomorphological changes of joints in rat model of chronic adjuvant arthritis.Methods: The rat chronic adjuvant arthritis model was established by subcutaneous injection of 0.1 ml of complete Freund’s adjuvant to the left hind sole. Forty Wistar rats were randomly divided into the model group

the low frequency (2 Hz) EA group

the high frequency EA (100 Hz) group and the body acupuncture group. After being modeled except the model group

the other three groups were treated with EA or body acupuncture in Yanglingquan points (bilateral) for 3 weeks

the left ankle joints and metatarsal joints of rats were taken for pathological examination by fixing with 10% formalin and embedding in paraffin

sectioning and staining with HE.Results: Obvious inflammatory cell infiltration

loosened synovial tissue

damage of articular cartilage and proliferation of synovial cells and granulation tissue were observed in the sections of joints in model rats. These pathological changes were significantly improved after treatment

and the effect in the high frequency EA group were significantly superior to that in the low frequency EA and body acupuncture group.Conclusion: High frequency EA could significantly improve the pathomorphological changes of joints in chronic adjuvant arthritis rat models.

Abstract

the low frequency (2 Hz) EA group

the high frequency EA (100 Hz) group and the body acupuncture group. After being modeled except the model group

the other three groups were treated with EA or body acupuncture in Yanglingquan points (bilateral) for 3 weeks

the left ankle joints and metatarsal joints of rats were taken for pathological examination by fixing with 10% formalin and embedding in paraffin

sectioning and staining with HE.Results: Obvious inflammatory cell infiltration

loosened synovial tissue

关键词

chronic adjuvant arthritiselectro-acupuncture therapypathomorphology

Keywords

chronic adjuvant arthritiselectro-acupuncture therapypathomorphology

references

LI YK, edit. Experimental Methodology of Chinese Herbal Medical Pharmacology. Shanghai: Shanghai Publishing House of Sciences and Technology, 1991: 305.

WANG HB, DONG XT, WANG SK, et al. Effect of electroacupuncture with various frequency on pain threshold and plasma cyclic nucleotide in rats with acute experimental arthritis. Chinese Acupuncture Moxibustion1999; 19(3): 170–172.

TANG ML, SONG XG, HOU ZM, et al. Experimental study on anti-inflammatory immune effect of moxibustion. Chines Acupuncture &. Moxibustion 1997; 17(4): 233–235.

YUAN J, TANG ZL, SONG XG, et al. Morphological observation on effect of moxibustion on adjuvant arthritis in rats. Acupuncture Research 1997;22(3): 179–180.

YANG SY, LIU JZ, FENG SL, et al. Study on effect of bee puncturing on joint of rat with adjuvant arthritis. Bulletin of Guangzhou University of TCM 2001; 18(3): 218–221.

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