Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image

Zhou Sheng-nian; Zhou Guo-yu; Liu Li-qing

doi:10.1007/BF02836378

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Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image

Updated：2021-08-27

- Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image
- Chinese Journal of Integrative Medicine Vol. 10, Issue 2, Pages: 107-111(2004)
- Affiliations：
  
  1. Neurological Department of Qilu Hospital, Shandong University,Jinan
  2. Western Medicine Department, Shandong University of Traditional Chinese Medicine,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836378
  CLC：
- Published：2004，
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Sheng-nian, Z., Guo-yu, Z. & Li-qing, L. Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image., Chin. J. Integr. Med. 10, 107–111 (2004). https://doi.org/10.1007/BF02836378

Zhou Sheng-nian, Zhou Guo-yu, Liu Li-qing. Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image. [J]. Chinese Journal of Integrative Medicine 10(2):107-111(2004)
Sheng-nian, Z., Guo-yu, Z. & Li-qing, L. Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image., Chin. J. Integr. Med. 10, 107–111 (2004). https://doi.org/10.1007/BF02836378 DOI：

Zhou Sheng-nian, Zhou Guo-yu, Liu Li-qing. Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image. [J]. Chinese Journal of Integrative Medicine 10(2):107-111(2004) DOI： 10.1007/BF02836378.

摘要

Objective: To investigate the influence of Tongxinluo capsule (TXL) on regional cerebral blood flow (rCBF) with 99mTc-ECD single photon emission computed tomography (SPECT) brain perfusion imaging

and to observe the therapeutic effects of TXL on acute small cerebral infarction (ASCI).Methods: Thirty-four patients with ASCI were enrolled and randomly divided into two groups: the control group (n = 17) was treated with the conventional treatment

i.e. 1. 0g of Citicoline added into 300 ml normal saline for intravenous dripping daily for 2 weeks and 0.8 g of Piracetam taken three times a day orally for 4 weeks

and the treatment group (n = 17) was treated additionally with 4 TXL capsules three times a day for 4 weeks besides the conventional treatment. The 99mTc-ECD SPECT brain perfusion imaging was performed before and after treatment to observe the change of rCBF

and the neurological deficit was evaluated by Edinburgh-Scandinavia stroke scale (SSS) scores and Barthel index (BI) at the same time.Results: After treatment

the rCBF in the treatment group was significantly improved (P<0.01)

while that in the control group remained unchanged

with the comparison of the rCBF in the two groups after treatment showing significant difference (P<0.01). In addition

the SSS score was significantly lower and Bl significantly higher in the treatment group than those in the control group respectively after treatment.Conclusion: TXL could effectively improve rCBF and lessen the neurological deficit symptoms in patients with ASCI.

Abstract

Objective: To investigate the influence of Tongxinluo capsule (TXL) on regional cerebral blood flow (rCBF) with 99mTc-ECD single photon emission computed tomography (SPECT) brain perfusion imaging

i.e. 1. 0g of Citicoline added into 300 ml normal saline for intravenous dripping daily for 2 weeks and 0.8 g of Piracetam taken three times a day orally for 4 weeks

and the neurological deficit was evaluated by Edinburgh-Scandinavia stroke scale (SSS) scores and Barthel index (BI) at the same time.Results: After treatment

the rCBF in the treatment group was significantly improved (P<0.01)

while that in the control group remained unchanged

with the comparison of the rCBF in the two groups after treatment showing significant difference (P<0.01). In addition

关键词

Cerebral InfarctionTonxinluo capsuleCerebral Blood Flowtherapeutic effectssingle photon emission computed tomography

Keywords

Cerebral InfarctionTonxinluo capsuleCerebral Blood Flowtherapeutic effectssingle photon emission computed tomography

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Center for Evidence-Based Medicine, Xuanwu Hospital, affiliated to Capital Medical University

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Department of Nuclear Medicine, Peking University Shenzhen Hospital

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