Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model

Yang Zhen-jiang; Zhao Xia; Zou Ying-zhen; Feng Yu-li; Dai Ling

doi:10.1007/BF02836385

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Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model

Updated：2021-08-27

- Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model
- Chinese Journal of Integrative Medicine Vol. 10, Issue 2, Pages: 127-130(2004)
- Affiliations：
  
  Shenzhen Municipal TCM Hospital,Guangdong
- Author bio：
- Funds：
  
  This study was supported by Guangdong Provincial TCM Administration Bureau (No. 98107)
- DOI：10.1007/BF02836385
  CLC：
- Published：2004，
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Zhen-jiang, Y., Xia, Z., Ying-zhen, Z. et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model., Chin. J. Integr. Med. 10, 127–130 (2004). https://doi.org/10.1007/BF02836385

Yang Zhen-jiang, Zhao Xia, Zou Ying-zhen, et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model. [J]. Chinese Journal of Integrative Medicine 10(2):127-130(2004)
Zhen-jiang, Y., Xia, Z., Ying-zhen, Z. et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model., Chin. J. Integr. Med. 10, 127–130 (2004). https://doi.org/10.1007/BF02836385 DOI：

Yang Zhen-jiang, Zhao Xia, Zou Ying-zhen, et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model. [J]. Chinese Journal of Integrative Medicine 10(2):127-130(2004) DOI： 10.1007/BF02836385.

摘要

Objective: To study the effect of Suiqing Pill (SQP)

a TCM compound drug that can activate blood circulation and get rid of blood stasis

on angiogenesis in tumor and its possible mechanism.Method: BALB/c nude mice were inoculated with melanoma cell line B16 at right armpit subcutaneously to establish cancer spontaneous metastasis model. Levels of microvessel density (MVD)

vascular endothelial growth factor (VEGF) and protein expression of matrix metalloproteinase-2 (MMP-2) in tumor tissues were observed and compared.Results: Strong expression of anti-Factor VIII (FVIII) related antigen and plentiful tumor angiogenesis were seen in model control animals

while in the high-dose and low-dose SQP treated model mice

MVD was inhibited by 33.5% and 22.6% respectively (P<0.01

P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups.Conclusion: SQP could inhibit tumor angiogenesis

protein expression of VEGF and MMP-2 in nude mice B16 melanoma models.

Abstract

Objective: To study the effect of Suiqing Pill (SQP)

a TCM compound drug that can activate blood circulation and get rid of blood stasis

while in the high-dose and low-dose SQP treated model mice

MVD was inhibited by 33.5% and 22.6% respectively (P<0.01

P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups.Conclusion: SQP could inhibit tumor angiogenesis

protein expression of VEGF and MMP-2 in nude mice B16 melanoma models.

关键词

Suiqing Pilltumor angiogenesisvascular endothelial growth factormatrix metalloproteinase

Keywords

Suiqing Pilltumor angiogenesisvascular endothelial growth factormatrix metalloproteinase

references

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