Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland

Qian Li-qi; Pei Xiao-hua; Chen Rong-ming; Xu Zhi-yin

doi:10.1007/BF02836386

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Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland

Updated：2021-08-27

- Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland
- Chinese Journal of Integrative Medicine Vol. 10, Issue 2, Pages: 131-134(2004)
- Affiliations：
  
  1. Nanjing Medical University,China
  2. Beijing University of Chinese Medicine,China
  3. Pharmaceutical Co. Ltd., Nanjing University of Traditional Chinese Medicine,China
  4. Jiangsu Provincial Hospital of Chinese Medicine,China
- Author bio：
- Funds：
  
  This study was supported by Jiangsu Provincial Administration Bureau of Traditional Chinese Medicine [No. SZ 95-B18]
- DOI：10.1007/BF02836386
  CLC：
- Published：2004，
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Li-qi, Q., Xiao-hua, P., Rong-ming, C. et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland., Chin. J. Integr. Med. 10, 131–134 (2004). https://doi.org/10.1007/BF02836386

Qian Li-qi, Pei Xiao-hua, Chen Rong-ming, et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland. [J]. Chinese Journal of Integrative Medicine 10(2):131-134(2004)
Li-qi, Q., Xiao-hua, P., Rong-ming, C. et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland., Chin. J. Integr. Med. 10, 131–134 (2004). https://doi.org/10.1007/BF02836386 DOI：

Qian Li-qi, Pei Xiao-hua, Chen Rong-ming, et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland. [J]. Chinese Journal of Integrative Medicine 10(2):131-134(2004) DOI： 10.1007/BF02836386.

摘要

Objective: To investigate the effects of Lirukang oral liquid (LRK) on release of neurotransmitter in rats with hyperplasia of mammary glands (HMG) and to explore its mechanism.Methods: Sixty rats were divided into six groups

the normal control group

the model control group

the large dosage (3.6g/kg) and the small dosage (1.8g/kg) LRK groups

the Ruzengning (RZN

2.5g/kg) group and the tamoxifen (TAM

5mg/kg) group

10 in each group. Except those in the normal control group

all the animals were made into rat model of HMG by intraperitoneal injection of estradiol benzoate. Levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) in hypothalamus and mammary gland in rats were detected by fluorescence luminosity assay

and level of prolactin (PRL) in serum was detected by radioimmunoassay.Results: In the model group

the level of DA reduced significantly (P<0.01)

and 5-HT and PRL increased obviously (P<0.01). Compared with the model group

the LRK groups of both dosages and the TAM group had their level of DA significantly increased (P<0.01)

and level of 5-HT significantly decreased (P<0.01). The serum PRL in both LRK groups was significantly decreased (P<0.01). No obvious changes in DA

5-HT and PRL were found in the RZN group.Conclusion: LRK and TAM have similar effects in regulating the release of neurotransmitter in hypothalamus and mammary gland and serum content of estrogen in the animal models of HMG.

Abstract

the normal control group

the model control group

the large dosage (3.6g/kg) and the small dosage (1.8g/kg) LRK groups

the Ruzengning (RZN

2.5g/kg) group and the tamoxifen (TAM

5mg/kg) group

10 in each group. Except those in the normal control group

and level of prolactin (PRL) in serum was detected by radioimmunoassay.Results: In the model group

the level of DA reduced significantly (P<0.01)

and 5-HT and PRL increased obviously (P<0.01). Compared with the model group

the LRK groups of both dosages and the TAM group had their level of DA significantly increased (P<0.01)

and level of 5-HT significantly decreased (P<0.01). The serum PRL in both LRK groups was significantly decreased (P<0.01). No obvious changes in DA

关键词

Lirukang oral liquidhyperplasia of mammary glandsneurotransmitterrats

Keywords

Lirukang oral liquidhyperplasia of mammary glandsneurotransmitterrats

references

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Research Center of Rehabilitation Science and Technology, School of Life Science and Technology, Xi’an Jiaotong University

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