Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo

Qu Xun; Zheng Guang-juan; Liu Fu-li; Zhang Dan; Zhang Jing; Yang Mei-xiang; Xia Li-ying

doi:10.1007/BF02836389

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Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo

Updated：2021-08-27

- Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo
- Chinese Journal of Integrative Medicine Vol. 10, Issue 2, Pages: 138-140(2004)
- Affiliations：
  
  1. Institute of Basic Medicine, Qilu Hospital of Shandong University,Jinan
  2. Shandong University of Traditional Chinese Medicine,China
  3. Institute of Gastroenterology, Shandong Provincial Hospital,China
- Author bio：
- Funds：
  
  This program was funded by Health Office of Shandong Province (No. 2001CA1CDA1) and Chinese Medicine Bureau of Shandong Province (No. 99-46)
- DOI：10.1007/BF02836389
  CLC：
- Published：2004，
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Xun, Q., Guang-juan, Z., Fu-li, L. et al. Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo., Chin. J. Integr. Med. 10, 138–140 (2004). https://doi.org/10.1007/BF02836389

Qu Xun, Zheng Guang-juan, Liu Fu-li, et al. Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo. [J]. Chinese Journal of Integrative Medicine 10(2):138-140(2004)
Xun, Q., Guang-juan, Z., Fu-li, L. et al. Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo., Chin. J. Integr. Med. 10, 138–140 (2004). https://doi.org/10.1007/BF02836389 DOI：

Qu Xun, Zheng Guang-juan, Liu Fu-li, et al. Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo. [J]. Chinese Journal of Integrative Medicine 10(2):138-140(2004) DOI： 10.1007/BF02836389.

摘要

Objective: To study the effects of basil polysaccharide (BP) in inhibiting tumor growth and metastasis in vivo.Methods: One hundred and fifty mice were randomly divided into five groups to observe the effect on tumor growth after H22 cancer cells had been transplanted subcutaneously into their right armpit region and treated with different dosages (5 mg/kg

2.5 mg/kg and 1.25 mg/kg) of BP for 14 days

with Mitomycin (Mit-C) used as control. Another 150 mice were randomly divided into three groups

models of tumor metastasis in the lung by various paths (lymphatic

blood circulatory and spontaneous) were established respectively. They were treated with BP or Mit-C to observe the influence of treatments on tumor metastasis by various paths.Results: BP of various dosages showed no effect on tumor growth

but in high and middle dosage

it could significantly reduce the number or metastasis nodules (P<0.05). Conclubsion: BP has a tumor metastasis inhibitory effect

which might be one of the candidates for new anti-tumor metastasis agents. Its mechanism may be blocking the function of platelets in the tumor metastasis progress.

Abstract

2.5 mg/kg and 1.25 mg/kg) of BP for 14 days

with Mitomycin (Mit-C) used as control. Another 150 mice were randomly divided into three groups

models of tumor metastasis in the lung by various paths (lymphatic

but in high and middle dosage

it could significantly reduce the number or metastasis nodules (P<0.05). Conclubsion: BP has a tumor metastasis inhibitory effect

which might be one of the candidates for new anti-tumor metastasis agents. Its mechanism may be blocking the function of platelets in the tumor metastasis progress.

关键词

Chinese Medicinebasil polysaccharidecell proliferationanti-tumor metastasis

Keywords

Chinese Medicinebasil polysaccharidecell proliferationanti-tumor metastasis

references

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Plotnikov MB, Maslov MIu, Aliev ol, et al. Disorders of hemorrheology in Walker’s carcinosarcoma-256 and in cyclophosphamide treatment of rats. Vopr Oncol 2001; 47(3): 335–337.

von Tempelhoff GF, Nieman F, Heilmann L, et al. Association between hemorrheology, thrombosis and cancer survival in patients with gynecologic malignancy. Clin Hemorrheol Microcirc 2000; 22(2): 107–130.

Yang ZH, Shi YL, Ran YL. Generation and characterization of monoclonal antibodies to human vascular endothelial growth factor 165 and the effect on primary and metastatic tumor growth of breast tumor. Chin J Immunol 1999; 15 (9): 414–417.

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