Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant

Zhou Lan-lan; Ming Liang; Ma Chuan-geng; Fan Mei-zhen; Cheng Yan; Jiang Qin

doi:10.1007/BF02836413

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Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant

Updated：2021-08-27

- Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant
- Chinese Journal of Integrative Medicine Vol. 10, Issue 3, Pages: 221-225(2004)
- Affiliations：
  
  1. Department of Pharmacology, Anhui Medical University,Hefei,China
  2. Anhui Agricultural University,Hefei
- Author bio：
- Funds：
  
  Project was supported by Natural Science Fund and Science Fund of Education Bureau, Anhui Province (No. 44415 and No. 2001KJ130)
- DOI：10.1007/BF02836413
  CLC：
- Published：2004，
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Lan-lan, Z., Liang, M., Chuan-geng, M. et al. Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant., Chin. J. Integr. Med. 10, 221–225 (2004). https://doi.org/10.1007/BF02836413

Zhou Lan-lan, Ming Liang, Ma Chuan-geng, et al. Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant. [J]. Chinese Journal of Integrative Medicine 10(3):221-225(2004)
Lan-lan, Z., Liang, M., Chuan-geng, M. et al. Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant., Chin. J. Integr. Med. 10, 221–225 (2004). https://doi.org/10.1007/BF02836413 DOI：

Zhou Lan-lan, Ming Liang, Ma Chuan-geng, et al. Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant. [J]. Chinese Journal of Integrative Medicine 10(3):221-225(2004) DOI： 10.1007/BF02836413.

摘要

Objective: To study the antidepressant effects and its mechanism of bioactive compounds (metabolite extract) from entomogenous fungi (BCEF) on experimental animal models of depression.Methods: The antidepressant effect of BCEF was examined on the acquired models of depression (rats and mice in forced swimming test) and unpredictable chronic stress mouse models. The behavior alterations were assayed by detecting the duration of immobility in forced swimming test. UV spectrophotometer analysis technique was used to detect the activity of Superoxide dismutase (SOD)

glutathione peroxidase (GSH-PX) and catalase (CAT) in mice brain mitochondria; and colorimetric method was used to detect the content of malondealdehyde (MDA)

nitrogen oxide (NO) in rat brain cytoplasm and mitochondria.Results: BCEF (25

100 mg/kg) could obviously shorten the immobility time in forced swimming mice and BCEF (50

100 mg/kg) could obviously shorten the immobility time in forced swimming rats. Both of them showed some extent of dose-effect relationship. BCEF (50

100 mg/kg) could significantly inhibit the increase of MDA and NO content in brain mitochondria and cytoplasm in chronic unpredictable stress models. BCEF (25

100 mg/kg) could obviously enhance the activities of SOD and GSH-PX. BCEF (50 mg/kg) also enhances the activities of CAT.Conclusion: BCEF has antidepressant effects in depressed animal models. The anti-oxidation may be one of the important mechanisms.

Abstract

glutathione peroxidase (GSH-PX) and catalase (CAT) in mice brain mitochondria; and colorimetric method was used to detect the content of malondealdehyde (MDA)

nitrogen oxide (NO) in rat brain cytoplasm and mitochondria.Results: BCEF (25

100 mg/kg) could obviously shorten the immobility time in forced swimming mice and BCEF (50

100 mg/kg) could obviously shorten the immobility time in forced swimming rats. Both of them showed some extent of dose-effect relationship. BCEF (50

100 mg/kg) could significantly inhibit the increase of MDA and NO content in brain mitochondria and cytoplasm in chronic unpredictable stress models. BCEF (25

关键词

entomogenous fungidepressionmodellipid peroxidation

Keywords

entomogenous fungidepressionmodellipid peroxidation

references

Fenglin Hu, Karen S, Stefka S, et al. Radical scavengers from the entomogeous deuteromycete beauveria amorpha. Planta Medica 2002;68: 64–66.

Zhou LL, Min L, Cheng Y, et al. Antidepressant effects of bioactive compounds from entomogenous fungi in mice models of depression. Chin Pharmacol Bull 2003; 19(5): 568–570.

Djaldetti R, Robinson DS. New drugs in the future treatment of Parkinson ’ s disease. J Neurol 2002; 249 (Suppl2): 30–35.

Emisson L, Saetre P, Balciuniene J, et al. Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer’s disease patients. Neurosci Lett 2002; 326.(1): 56–60.

Robinson DS. Monoamine oxidase inhibitors: a new generation. Psychopharmacol Bull 2002; 36(3): 124–138.

Cristiano MS, Sandra L S, Jairza MBM, et al. Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats. Arq Neuropsiquiatr 2002;60(4): 928–932.

Takahiro N, Takaaki Y, Joji U, et al. Antidepressantlike effect of apigenin and 2,4, 5-trimethoxycin-namic acids from perilla frutescens in the forced swimming test. Biol Pharm Bull 2002;26(4): 474–480.

D’Aquila PS, Brain P, Willer P. Effects of chronic mild stress on performance in behavioral tests relevant to anxiety and depression. Physiol Behav 1994; 56 (5): 861–867.

Porsot RD, Anton G, Blavet N, et al. Behavioral despair in rats: a new model sensitive to anti-depressants. Eur J Pharmacol 1978;479(4): 379–391.

Keck ME, Welt T, Poet A, et al. Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. Neuropsychopharmacol 2001;24 (4): 337–349.

Thomas AJ, Perry R, Barber R, et al. Pathologies and pathological mechanisms for white matter hyperintensities in depression. Ann N Y Acad Sci 2002;1997: 333–340.

Olivenza R, Moro MA, Lizasoain T, et al. Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex. J Neurochem 2000;74(2): 785–791.

Sapol sky RM. The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biopsychiatry 2000;48: 713–714.

Willer P. Animal models as stimulations of depression. Trends Pharmacol Sci 1991; 12(4): 131–136.

Willer P. Validity, reliability and utility of the chronic mild stress model of depression: a 10 -year review and evaluation. Psychopharmacol (Berl) 1997; 134(4): 319–329.

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Traditional Chinese Medicine Research and Development Center, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

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