Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel

Zhao Jian-xiong; Wei Zi-tai; Zhu Yu-zhen; Wang Xue-xi; Yin Chun; Li Hui; Dang Zong-yan; Meng Li-hong; Yang Zheng-fang

doi:10.1007/BF02836424

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Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel

Updated：2021-08-27

- Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel
- Chinese Journal of Integrative Medicine Vol. 10, Issue 4, Pages: 254-258(2004)
- Affiliations：
  
  1. Institute of Integrative Chinese and Western Medicine, Lanzhou Medical College,Lanzhou
  2. Department of Cardiovascular Diseases, Workers’ Hospital, Jinchuan Co.,Gansu Province
- Author bio：
- Funds：
  
  Project supported by Scientific Research Fund Item of Gansu Provincial Education Department (No. 023-01)
- DOI：10.1007/BF02836424
  CLC：
- Published：2004，
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Jian-xiong, Z., Zi-tai, W., Yu-zhen, Z. et al. Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel., Chin. J. Integr. Med. 10, 254–258 (2004). https://doi.org/10.1007/BF02836424

Zhao Jian-xiong, Wei Zi-tai, Zhu Yu-zhen, et al. Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel. [J]. Chinese Journal of Integrative Medicine 10(4):254-258(2004)
Jian-xiong, Z., Zi-tai, W., Yu-zhen, Z. et al. Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel., Chin. J. Integr. Med. 10, 254–258 (2004). https://doi.org/10.1007/BF02836424 DOI：

Zhao Jian-xiong, Wei Zi-tai, Zhu Yu-zhen, et al. Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel. [J]. Chinese Journal of Integrative Medicine 10(4):254-258(2004) DOI： 10.1007/BF02836424.

摘要

Objective: To study the clinical effect of Fuzheng Jiedu granule (FJG) and its influence on serum nitric oxide (NO)

nitric oxide synthase (NOS) and microelements in patients with coronary heart disease who are in long-term contact with nickel.Methods: Sixty patients were randomly divided into two groups

the treated group and the control group

30 in each group. Conventional Western medicinal treatment was applied to both groups

but to the treated group

FJG was given additionally by oral intake

and the therapeutic course for both groups was 4 weeks. Besides

a health control group was set up with 15 healthy subjects selected from the same area

who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO

NOS and microelements were observed before and after treatment.Results: The total effective rate on clinical symptoms in the treated group was 93.3% and that in the control group 63.3%

comparison between the two showing significant difference (P<0.05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively

which also showed significant difference (P<0.05). After treatment

levels of serum NO

NOS

Zn and Ca increased and those of Ni

Mn and Fe decreased significantly (P<0.05 orP<0.01) in the treated group

while in the control group

changes in these laboratory indexes were insignificant.Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements

help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.

Abstract

Objective: To study the clinical effect of Fuzheng Jiedu granule (FJG) and its influence on serum nitric oxide (NO)

nitric oxide synthase (NOS) and microelements in patients with coronary heart disease who are in long-term contact with nickel.Methods: Sixty patients were randomly divided into two groups

the treated group and the control group

30 in each group. Conventional Western medicinal treatment was applied to both groups

but to the treated group

FJG was given additionally by oral intake

and the therapeutic course for both groups was 4 weeks. Besides

a health control group was set up with 15 healthy subjects selected from the same area

who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO

NOS and microelements were observed before and after treatment.Results: The total effective rate on clinical symptoms in the treated group was 93.3% and that in the control group 63.3%

comparison between the two showing significant difference (P<0.05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively

which also showed significant difference (P<0.05). After treatment

levels of serum NO

NOS

Zn and Ca increased and those of Ni

Mn and Fe decreased significantly (P<0.05 orP<0.01) in the treated group

while in the control group

changes in these laboratory indexes were insignificant.Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements

help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.

关键词

nickelFuzheng Jiedu granulenitric oxide synthaseNitric Oxidemicroelement

Keywords

nickelFuzheng Jiedu granulenitric oxide synthaseNitric Oxidemicroelement

references

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Zhu YZ, Zhao JX, Wang XX, et al. Effect of Fuzheng Jiedu decoction in preventing and treating the effect of nickel on myocardial mitochondrial enzyme activity. J Health Toxicol 2001;15(1): 35–36.

Zhou W, Wang SX, Wei MT, et al. Effect of lead on nitric oxide synthase and NO in hippocampus of rats. Industrial Health Occup Dis 2002;28(4): 222–224.

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Zhao JX, Zhu YZ, Sun YB, et al. Experimental study on effect of Chinese drugs on activity of two myocardial enzymes and ECG in preventing and treating nickel damaged rats. Chin J Occup Med 2001;28(4): 15–16.

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Uematso M, Ohara Y, Navas JP, et al. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 1995;269: C1371–1378.

Tan XF, Tian F. Effect of Huoxue Baoxin granule on NO and cardiovascular regulatory peptides in patients with coronary arterial atherosclerostic heart disease and angina pectoris. Chin J Integr Tradit West Med Intens Crit Care 1999;6(2): 56–58.

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