Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia

Liu Zhi-gao; Yu Xi-yong

doi:10.1007/BF02836425

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Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia

Updated：2021-08-27

- Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia
- Chinese Journal of Integrative Medicine Vol. 10, Issue 4, Pages: 259-262(2004)
- Affiliations：
  
  1. Department of Cardiology, Affiliated Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan
  2. Guangdong Provincial Institute of Cardiovascular Diseases,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02836425
  CLC：
- Published：2004，
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Zhi-gao, L., Xi-yong, Y. Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia., Chin. J. Integr. Med. 10, 259–262 (2004). https://doi.org/10.1007/BF02836425

Liu Zhi-gao, Yu Xi-yong. Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 10(4):259-262(2004)
Zhi-gao, L., Xi-yong, Y. Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia., Chin. J. Integr. Med. 10, 259–262 (2004). https://doi.org/10.1007/BF02836425 DOI：

Liu Zhi-gao, Yu Xi-yong. Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 10(4):259-262(2004) DOI： 10.1007/BF02836425.

摘要

Objective: To investigate the effects of Xuezhikang capsule (XZK) on blood lipids level

platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia.Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups

the XZK group (n = 38) treated with XZK 600mg

taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day

with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids

including total cholesterol (TC)

triglyceride (TG)

high and low density lipoprotein cholesterol (HDL-C and LDL-C)

plasma GMP-140

fibrinogen (FIB)

tissue plasminogen activator (t-PA)

plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control.Results: Before treantment the levels of TC

TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P<0.05 orP<0.01). After 4–8 weeks of XZK treatment

the levels of TC

LDL-C and FIB and activities of GMP-140 and PAI-1 were obviously lowered (P<0.05 orP<0.01). But in the SIM group there was no obvious change in FIB (P>0.05)

instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (P<0.05 orP<0.01).Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function

besides its lipids lowering effect.

Abstract

Objective: To investigate the effects of Xuezhikang capsule (XZK) on blood lipids level

platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia.Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups

the XZK group (n = 38) treated with XZK 600mg

taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day

with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids

including total cholesterol (TC)

triglyceride (TG)

high and low density lipoprotein cholesterol (HDL-C and LDL-C)

plasma GMP-140

fibrinogen (FIB)

tissue plasminogen activator (t-PA)

TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P<0.05 orP<0.01). After 4–8 weeks of XZK treatment

the levels of TC

LDL-C and FIB and activities of GMP-140 and PAI-1 were obviously lowered (P<0.05 orP<0.01). But in the SIM group there was no obvious change in FIB (P>0.05)

besides its lipids lowering effect.

关键词

Xuezhikang capsuleSimvastatinhyperlipidemiaplatelet α-granule membrane glycoproteincoagulation-fibrinolysis

Keywords

Xuezhikang capsuleSimvastatinhyperlipidemiaplatelet α-granule membrane glycoproteincoagulation-fibrinolysis

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Related Institution

Department of Hepatology, Zhejiang Hospital of Traditional Chinese Medicine

Department of Traditional Chinese Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University

Department of Endocrinology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

Shandong University of TCM

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