Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis

Shen Xiao-jun; Shi Yun-ju; Wang Ling

doi:10.1007/BF02836426

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Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis

Updated：2021-08-27

- Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis
- Chinese Journal of Integrative Medicine Vol. 10, Issue 4, Pages: 263-266(2004)
- Affiliations：
  
  1. Henan Chinese Medical College,Zhengzhou
  2. School of Medicine, Zhengzhou Railway Advanced Professional College,China
  3. Medical Colloge, Zhengzhou University,China
- Author bio：
- Funds：
  
  Project supported by Science and Technology Committee of Zhengzhou Railway Department (No. 03W30)
- DOI：10.1007/BF02836426
  CLC：
- Published：2004，
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Xiao-jun, S., Yun-ju, S. & Ling, W. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis., Chin. J. Integr. Med. 10, 263–266 (2004). https://doi.org/10.1007/BF02836426

Shen Xiao-jun, Shi Yun-ju, Wang Ling. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis. [J]. Chinese Journal of Integrative Medicine 10(4):263-266(2004)
Xiao-jun, S., Yun-ju, S. & Ling, W. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis., Chin. J. Integr. Med. 10, 263–266 (2004). https://doi.org/10.1007/BF02836426 DOI：

Shen Xiao-jun, Shi Yun-ju, Wang Ling. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis. [J]. Chinese Journal of Integrative Medicine 10(4):263-266(2004) DOI： 10.1007/BF02836426.

摘要

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis

and the effect of Tongmai Jiangzhi oral liquid (TMJZ) on cytokines through observing serum P-selectins (Ps)

von Willebrand (vWF)

and D-dimer (D-D) in atherosclerosis (AS) patients.Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33

treated with TMJZ

10 ml each time

three times a day) and the control group (n = 30

treated with Lovastatin

10 mg

once daily). The levels of serum lipids (enzymatic methods)

vWF

and D-D were measured before and after 8 weeks of treatment.Results: Serum total cholesterol (TC)

triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C)

apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 orP<0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps

vWF

and D-D also declined (P<0.05) after treatment. There was no significant difference between the treated and the control groups in these parameters except serum HDL-C level.Conclusion: TMJZ has good therapeutic effect in regulating serum lipids

improving endothelial cell function

inhibiting activation of platelets

and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

Abstract

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis

and the effect of Tongmai Jiangzhi oral liquid (TMJZ) on cytokines through observing serum P-selectins (Ps)

von Willebrand (vWF)

and D-dimer (D-D) in atherosclerosis (AS) patients.Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33

treated with TMJZ

10 ml each time

three times a day) and the control group (n = 30

treated with Lovastatin

10 mg

once daily). The levels of serum lipids (enzymatic methods)

vWF

and D-D were measured before and after 8 weeks of treatment.Results: Serum total cholesterol (TC)

triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C)

apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 orP<0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps

vWF

improving endothelial cell function

inhibiting activation of platelets

and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

关键词

Tongmai Jiangzhi oral liquidatherosclerosisP-selectinvon Willebrand factorD-dimer

Keywords

Tongmai Jiangzhi oral liquidatherosclerosisP-selectinvon Willebrand factorD-dimer

references

Liang YJ. Cellular connective communication and atherosclerosis. Dev Cardiovasc Dis 2001; 22(3): 175–177.

Editorial Committee of Chinese Journal of Cardiovascular Diseases. Academic Committee of Prevention and Treatment on Abnormal Lipidemia. The suggestion of prevention and treatment on abnormal lipidemia. Chin J Cardiovasc Dis 1997; 25(3): 169–175.

Johnson-Tidey RR, McGregor JL, Taylor PR. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques: co-expression with intercellular adhesion molecule-1. Am J Pathol 1994; 144: 952–961.

Kaikita K, Ogawa H, Yasue H, et al. Soluble P-Selectin is released into the coronary circulation after coronary spasm. Circulation 1995; 92: 1726–1730.

Lu JM. Dysfunction of vascular endothelium and its investigation in coronary heart disease. Dev Cardiovasc Dis 2000; 21(6): 339–342.

Zhang HP. Disseminated intravascular coagulation. In: Jin Hui-ming editor. Pathophysiology. 5th ed. Beijing: People’s Medical Publishing House, 137–149

Meng ZX, Wu SM, Sun RJ, et al. The mechanism of Radix Salviae miltiorrhizae in preventing and treating atherosclerosis. J Cardiovasc Pulm Dis 1993; 12(1): 121–123.

Zhou XM, Lu ZY, Wang DW. The preliminary study of Salvia on its effect and mechanism in preventing and treating experimental arterial restenosis. Chin J Integr Tradit West Med (Chin) 1996; 16(8): 480–482.

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Traditional Chinese Medicine College of Xinjiang Medical University, Urumiqi

Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University

Lab, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou

Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University

Zhujiang Hospital, Southern Medical University

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