Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation

Lin Jian-jun; Jin Chang-nan; Zheng Min-lin; Ouyang Xue-nong; Zeng Jin-xiong; Dai Xi-hu

doi:10.1007/BF02836465

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Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation

Updated：2021-08-27

- Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation
- Chinese Journal of Integrative Medicine Vol. 11, Issue 2, Pages: 104-110(2005)
- Affiliations：
  
  1. Center of Hepatopathy, Xiamen Municipal TCM Hospital Affiliated to Fujian TCM College,Xiamen
  2. Department of Anatomy, Fujian TCM College,China
  3. Department of TCM Oncology, Fuzhou General Hospital of Nanjing Military Region,China
- Author bio：
- Funds：
  
  Supported by Fund for Young Researchers Set by Ministry of Health of Fujian Province(No. 2002-2-20)
- DOI：10.1007/BF02836465
  CLC：
- Published：2005，
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Jian-jun, L., Chang-nan, J., Min-lin, Z. et al. Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation., Chin. J. Integr. Med. 11, 104–110 (2005). https://doi.org/10.1007/BF02836465

Lin Jian-jun, Jin Chang-nan, Zheng Min-lin, et al. Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation. [J]. Chinese Journal of Integrative Medicine 11(2):104-110(2005)
Jian-jun, L., Chang-nan, J., Min-lin, Z. et al. Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation., Chin. J. Integr. Med. 11, 104–110 (2005). https://doi.org/10.1007/BF02836465 DOI：

Lin Jian-jun, Jin Chang-nan, Zheng Min-lin, et al. Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation. [J]. Chinese Journal of Integrative Medicine 11(2):104-110(2005) DOI： 10.1007/BF02836465.

摘要

Objective: To observe the short-term efficacy and safety of Shenqi mixture (SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with primary HCC of stage II – III

Karnofsky scoring ⩾50 scores and predicted survival period ⩾3 months were selected and randomly assigned into two groups

the treated group and the control group

36 in each. Microwave therapy was applied to both groups by double leads

60 W

800 sec once a week for two weeks. To the treated group

SQM was given additionally through oral intake of 20 ml

three times a day for 1 month. The changes in tumor size

main symptoms

serum level of alpha-fetoprotein (AFP)

immune function and adverse reaction were observed after treatment and the immune parameters of the patients were compared with 30 healthy persons in the normal control group.Results: (1) In the SQM treated group

after treatment 3 patients got completely remitted (CR)

24 partial remitted (PR)

4 unchanged (NC) and 5 progressively deteriorated (PD)

the effective rate being 75.00%; while in the control group

1 got CR

19 PR

9 NC and 7 PD

the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups

but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment

in the treated group

CD3+

CD4+

CD4+/CD8+ and NK activity were improved

Karnofsky scores increased and liver function bettered

with these improvements significantly superior to those in the control group (P<0. 01). (4) The improvement in symptoms such as hepatic region pain

fever

weakness

poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month

18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control group

showing significant difference (P<0.05).Conclusion: Combined therapy with SQM and microwave coagulation could not only kill the tumor and residue tumor cells to prevent recurrence

but also enhance the cellular immunity of organism. It is one of the effective therapies for patients with middle-advanced hepatocarcinoma

who have lost the chance of surgical operation. It could improve clinical symptoms

elevate the quality of life

prolong the survival period of patients

but shows no evident adverse reaction.

Abstract

Karnofsky scoring ⩾50 scores and predicted survival period ⩾3 months were selected and randomly assigned into two groups

the treated group and the control group

36 in each. Microwave therapy was applied to both groups by double leads

60 W

800 sec once a week for two weeks. To the treated group

SQM was given additionally through oral intake of 20 ml

three times a day for 1 month. The changes in tumor size

main symptoms

serum level of alpha-fetoprotein (AFP)

after treatment 3 patients got completely remitted (CR)

24 partial remitted (PR)

4 unchanged (NC) and 5 progressively deteriorated (PD)

the effective rate being 75.00%; while in the control group

1 got CR

19 PR

9 NC and 7 PD

the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups

but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment

in the treated group

CD3+

CD4+

CD4+/CD8+ and NK activity were improved

Karnofsky scores increased and liver function bettered

with these improvements significantly superior to those in the control group (P<0. 01). (4) The improvement in symptoms such as hepatic region pain

fever

weakness

poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month

18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control group

showing significant difference (P<0.05).Conclusion: Combined therapy with SQM and microwave coagulation could not only kill the tumor and residue tumor cells to prevent recurrence

but also enhance the cellular immunity of organism. It is one of the effective therapies for patients with middle-advanced hepatocarcinoma

who have lost the chance of surgical operation. It could improve clinical symptoms

elevate the quality of life

prolong the survival period of patients

but shows no evident adverse reaction.

关键词

Primary Hepatocarcinomaintegrated traditional Chinese and Western medicineShenqi mixturemicrowave coagulation

Keywords

Primary Hepatocarcinomaintegrated traditional Chinese and Western medicineShenqi mixturemicrowave coagulation

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