Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase

Hong Min-li; Yang Guo-zong; Chen Wen-xi; Gao Ling-yun; Cai Shao-hang; Dai Shun-zhen

doi:10.1007/BF02836500

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Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase

Updated：2021-08-27

- Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase
- Chinese Journal of Integrative Medicine Vol. 11, Issue 3, Pages: 179-182(2005)
- Affiliations：
  
  Zhangzhou Hospital of Traditional Chinese Medicine,Fujian
- Author bio：
- Funds：
  
  Supported by Young Scientific Research Fund of Department of Public Health of Fujian Province (No. 99-1-22);Imbursement Project of Office of Science and Technology of Zhangzhou (No. Z02048)
- DOI：10.1007/BF02836500
  CLC：
- Published：2005，
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Min-li, H., Guo-zong, Y., Wen-xi, C. et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase., Chin. J. Integr. Med. 11, 179–182 (2005). https://doi.org/10.1007/BF02836500

Hong Min-li, Yang Guo-zong, Chen Wen-xi, et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase. [J]. Chinese Journal of Integrative Medicine 11(3):179-182(2005)
Min-li, H., Guo-zong, Y., Wen-xi, C. et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase., Chin. J. Integr. Med. 11, 179–182 (2005). https://doi.org/10.1007/BF02836500 DOI：

Hong Min-li, Yang Guo-zong, Chen Wen-xi, et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase. [J]. Chinese Journal of Integrative Medicine 11(3):179-182(2005) DOI： 10.1007/BF02836500.

摘要

Objective: To evaluate the effect of Yufeining

a traditional Chinese medicine

on induced sputum interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD) at the stable phase.Methods: Thirty-six patients with COPD were divided into trial group (18 cases) and control group (18 cases) randomly. The trial group was treated with Yufeining pills taken orally for half a year; the control group was not given any medicine. Routine lung function was recorded before and after treatment. Total cell count (TCC)

differential cell counts (DCCs) and IL-8 in induced sputum were determined at the baseline and 6 months later.Results: The indices of lung function improved significantly after 6 months’ treatment in trial group (P<0.05); TCC and absolute neutrophil count decreased significantly compared with baseline in the trial group (P<0.05); Sputum IL-8 concentration dropped significantly after 6 months’ treatment

from a mean of 5.216 ± 2. 914 μg/L to 4.222 ± 2.140 μg/L (P<0.05). There were insignificant changes in the parameters in the control group between baseline and 6 months later.Conclusion: Yufeining could improve lung function

decrease sputum TCC

absolute neutrophil count and IL-8 concentration

and relieve airway inflammation in patients with COPD in the stable phase.

Abstract

Objective: To evaluate the effect of Yufeining

a traditional Chinese medicine

decrease sputum TCC

absolute neutrophil count and IL-8 concentration

and relieve airway inflammation in patients with COPD in the stable phase.

关键词

Chronic Obstructive Pulmonary Diseaseairway inflammationinterleukin-8Yufeining

Keywords

Chronic Obstructive Pulmonary Diseaseairway inflammationinterleukin-8Yufeining

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Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University

Department of Traditional Chinese Medicine, the 2nd Xiangya Hospital, Central South University

Department of Respiratory, Huaihe Hospital of Henan University

Department of Respiratory, Kaifeng Hospital of Traditional Chinese Medicine

Department of Respiratory, the Second People’s Hospital of Jiaozuo City

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