Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats

Wu Su-hui; Sun Jing-fen; Guo Shu-zhen

doi:10.1007/BF02836506

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Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats

Updated：2021-08-27

- Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats
- Chinese Journal of Integrative Medicine Vol. 11, Issue 3, Pages: 205-208(2005)
- Affiliations：
  
  Department of Obstetrics and Gynecology, The First Hospital, Shanxi Medical University,Taiyuan
- Author bio：
- Funds：
  
  Supported by Shanxi Key Technology R&D Program (No. 20022074)
- DOI：10.1007/BF02836506
  CLC：
- Published：2005，
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Su-hui, W., Jing-fen, S. & Shu-zhen, G. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats., Chin. J. Integr. Med. 11, 205–208 (2005). https://doi.org/10.1007/BF02836506

Wu Su-hui, Sun Jing-fen, Guo Shu-zhen. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats. [J]. Chinese Journal of Integrative Medicine 11(3):205-208(2005)
Su-hui, W., Jing-fen, S. & Shu-zhen, G. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats., Chin. J. Integr. Med. 11, 205–208 (2005). https://doi.org/10.1007/BF02836506 DOI：

Wu Su-hui, Sun Jing-fen, Guo Shu-zhen. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats. [J]. Chinese Journal of Integrative Medicine 11(3):205-208(2005) DOI： 10.1007/BF02836506.

摘要

Objective: To compare the therapeutic effect of Compound Recipe Gengniankang (GNK) with that of hormone replacement treatment (HRT) on climacteric female rats with osteoporosis

and to investigate the roles of estrogen and estrogen receptors in the mechanism of osteoporosis.Methods: Climacteric female rats with osteoporosis were chosen and divided into three groups (GNK group

HRT group and control group). Apoptosis of ovarian granulose cells was measured by terminal-deoxynucleotidyl transferae mediated nick end labeling (TUNEL) assay. Serum level of estrdiol (E2)

follicle stimulating hormone (FSH)

luteinizing hormone (LH) were determined by the method of radioimmunoassay (RIA). Reverse transcriptase polymerase chain reaction (RT-PCT) technology was used to evaluate the expression of estrogen receptor (ER) in bone. Bone mineral density (BMD) was measured by double energy X-ray absorption (DEXA).Results: In the climacteric rats

BMD

serum E2

ER mRNA expression in bone decreased remarkably

and serum FSH

LH and apoptosis of ovarian granulose cells increased obviously. After treating with GNK

all the indexes were reversed except serum E2. The increase of E2 was not significant.Conclusion: GNK is effective on climacteric osteoporosis female rats. Its role is performed not by increasing serum E2 but by enhancing ER in the bone and inhibiting apoptosis of ovarian granulose cells. GNK can deter further exhaustion of ovarian function.

Abstract

Objective: To compare the therapeutic effect of Compound Recipe Gengniankang (GNK) with that of hormone replacement treatment (HRT) on climacteric female rats with osteoporosis

HRT group and control group). Apoptosis of ovarian granulose cells was measured by terminal-deoxynucleotidyl transferae mediated nick end labeling (TUNEL) assay. Serum level of estrdiol (E2)

follicle stimulating hormone (FSH)

BMD

serum E2

ER mRNA expression in bone decreased remarkably

and serum FSH

LH and apoptosis of ovarian granulose cells increased obviously. After treating with GNK

关键词

Compound Recipe GengniankangOsteoporosisestrogenestrogen receptor

Keywords

Compound Recipe GengniankangOsteoporosisestrogenestrogen receptor

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