Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers

Li Bei; Shang Jing-chuan; Zhou Qi-xin

doi:10.1007/BF02836508

Your Location：

Home >

Browse articles >

Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers

Updated：2021-08-27

- Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers
- Chinese Journal of Integrative Medicine Vol. 11, Issue 3, Pages: 217-221(2005)
- Affiliations：
  
  1. Department of Pharmacology, Chongqing University of Medical Sciences,Chongqing
  2. Department of Chemistry, Chongqing University of Medical Sciences,China
- Author bio：
- Funds：
  
  Supported by Chongqing Board of Health (2004-B-31)
- DOI：10.1007/BF02836508
  CLC：
- Published：2005，
Scan for full text
Bei, L., Jing-chuan, S. & Qi-xin, Z. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers., Chin. J. Integr. Med. 11, 217–221 (2005). https://doi.org/10.1007/BF02836508

Li Bei, Shang Jing-chuan, Zhou Qi-xin. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers. [J]. Chinese Journal of Integrative Medicine 11(3):217-221(2005)
Bei, L., Jing-chuan, S. & Qi-xin, Z. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers., Chin. J. Integr. Med. 11, 217–221 (2005). https://doi.org/10.1007/BF02836508 DOI：

Li Bei, Shang Jing-chuan, Zhou Qi-xin. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers. [J]. Chinese Journal of Integrative Medicine 11(3):217-221(2005) DOI： 10.1007/BF02836508.

摘要

Objective: To study the effects of total alkaloids (TA) extracted from Rhizoma Coptis Chinensis on experimental gastric ulcer models.Methods: Four kinds of experimental ulcer models were established respectively by water-immersion stress

intragastric ethanol

acetic acid erosion

and pylorus ligation. The anti-ulcer effects of TA were evaluated

and compared with that of berberine (Ber) and cimetidine (Cim).Results: TA showed significant inhibitory effects on ulcerative formation induced by water-immersion stress

intragastric ethanol

and pylorus ligation in dose-dependent manner

and showed therapeutic effect on acetic acid erosion-inducing ulcer

in comparison with the control group. The anti-ulcer activity of Ber was less than TA containing equal content of Ber. TA significantly reduced the free acidity

total acidity and total acid output

but didn’t affect the gastric juice volume

gastric pepsin activity

adherent mucus quantity of stomach wall and free mucus dissolving in gastric juice. The suppressive activities of TA on gastric acid secretion didn’t occur when it was administered into dodecadactylon at a dose of 360 mg/kg wt. Moreover

when compared with Cim

the inhibitory effect of TA on gastric acid secretion isn’t proportional to the inhibitory effects on the formation of the 4 kinds of experimental ulcers.Conclusion: TA is a potent candidate in therapeutic drugs for treating gastric ulcer. Its anti-ulcer effective components and mechanism is not only related to Ber and inhibition of gastric acid

but also to other ingredients of TA and mechanism so far unknown.

Abstract

intragastric ethanol

acetic acid erosion

and pylorus ligation. The anti-ulcer effects of TA were evaluated

and compared with that of berberine (Ber) and cimetidine (Cim).Results: TA showed significant inhibitory effects on ulcerative formation induced by water-immersion stress

intragastric ethanol

and pylorus ligation in dose-dependent manner

and showed therapeutic effect on acetic acid erosion-inducing ulcer

in comparison with the control group. The anti-ulcer activity of Ber was less than TA containing equal content of Ber. TA significantly reduced the free acidity

total acidity and total acid output

but didn’t affect the gastric juice volume

gastric pepsin activity

when compared with Cim

but also to other ingredients of TA and mechanism so far unknown.

关键词

peptic ulcerRhizoma Coptis Chinensistotal alkaloidspharmacology

Keywords

peptic ulcerRhizoma Coptis Chinensistotal alkaloidspharmacology

references

Chen YF, Chen WW, Li RL, et al. Effects of “Zuojin pill and retro-Zuojin” on cold-syndrome and hot syndrome gastric mucosal lesion rats. Chin J Basic Med in Tradit Chin Med 2002;8 (10): 67–69.

Suenaga T, Shirakawa T, Harada N, et al. Mechanism of protective effects of ouren-gedoku-to and san’ ou-syashin-to on the gastric mucosa. Nippon Yakurigaku Zasshi 1991; 98 (4): 319–325.

Xu H, Yao QS, Zhou GL. Effect of ranitidine bismuth citrate on experimental gastric ulcer. Chin J New Drug 2001; 10 (3): 182–185.

Xu SY, Bian RN, Chen X. Experimental methodology of pharmacology. 3rd ed. Beijing: People’s Medical Publishing House, 2002: 1316–1317.

Lu G, Dong XY, Li YN. Effects of berberine on experimental gastric ulcer. Chin J New Gastroenterol 1996; 4 (3): 130–131.

Satoh K, Nagai F, Seto T, et al. The effects of kampo-formulation and the constituting crude drugs, prescribed for the treatment of peptic ulcer on H, K-ATPase activity. Yakugaku Zasshi 2001, 121 (2): 173–178.

Chen YF, Chen WW, Li RL, et al. Influence of Zuojin pill and retro-Zuojin pill on inflammatory and protective factors in rats with gastric mucosa lesion of cold and hot type. Chin J Integr Tradit West Med Dig 2003; 11 (3): 133–135.

Takase H. Protective effects of Ouren-gedoku-to and its herbs on the gastric mucosa. Jpn J Pharmacol 1989; 49: 301–308.

Wang XL, Jiao WL, Lu ZS, et al. Preliminary screening of Chinese herbal medicine in inhibiting helicobacter pylori. Chin J Integr Tradit West Med 1994; 14 (9): 534–536.

Wang WY, Chen KM, Guan YY. Effect of berberine hydrochloride on muscarinic receptors. Acta Pharmaceutica Sinica 1999; 34 (4): 260–263.

Cao JW, Luo HS, Yu BP, et al. Effects of berberine on intracellular calcium concentration in smooth muscle cells of guinea pig colon. Acta Physiologica Sinica 2000; 52 (4): 343–346.

Lu YN, Qiu QY. Effects of berberine on the levels of DTH and several important cytokines in the mice induced by DNFB. Chin Immun J 2000; 16 (3): 139–141.

Zhou H, Mineshita S. The effect of berberine chloride on experimental colitis in ratsin vivo andin vitro. J Pharmacol Exp Ther 2000; 294 (3): 822–829.

Hao Y, Qiu QY, Wu J. Effects of berberine on IL-1 or tumour necrosis factor induced polymorphonuclear leu-cocyte-endothelium adhesion. Chin J Pathophysiol 2000; 16 (7): 585–587.

Liu F, TB Ng. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci 2000; 66 (8): 725–735.

FULL TEXT LINK

More>

Views

355

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Chemistry and pharmacology of 4-hydroxylonchocarpin: A review

Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L.

Total alkaloids from Sophora alopecuroides L. increase susceptibility of extended-spectrum β-lactamases producing Escherichia coli isolates to cefotaxime and ceftazidime

Isobavachalcone: An overview

Ixora coccinea Linn.: Traditional uses, phytochemistry and pharmacology

Related Author

No data

Related Institution

Department of Biochemistry, Faculty of Science, University of Dschang, Yaounde

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde

Department of Pharmacognosy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran

Biology Department, Faculty of Biosciences, Tehran North Branch, Islamic Azad University, Tehran

Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China, College of Life Science, Ningxia University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰