Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease

Cheng Wen-li; Ke Yuan-nan; Shi Zai-xiang; Wang Ying; Chen Li; Ju Gao; Fan Shu-ying

doi:10.1007/BF02836515

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Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease

Updated：2021-08-27

- Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease
- Chinese Journal of Integrative Medicine Vol. 12, Issue 3, Pages: 166-170(2006)
- Affiliations：
  
  Department of National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02836515
  CLC：
- Published：2006，
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Wen-li, C., Yuan-nan, K., Zai-xiang, S. et al. Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease., Chin. J. Integr. Med. 12, 166–170 (2006). https://doi.org/10.1007/BF02836515

Cheng Wen-li, Ke Yuan-nan, Shi Zai-xiang, et al. Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease. [J]. Chinese Journal of Integrative Medicine 12(3):166-170(2006)
Wen-li, C., Yuan-nan, K., Zai-xiang, S. et al. Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease., Chin. J. Integr. Med. 12, 166–170 (2006). https://doi.org/10.1007/BF02836515 DOI：

Cheng Wen-li, Ke Yuan-nan, Shi Zai-xiang, et al. Clinical study on effect of garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease. [J]. Chinese Journal of Integrative Medicine 12(3):166-170(2006) DOI： 10.1007/BF02836515.

摘要

Objective: To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (CAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).Methods: Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months

and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA

with the observation proceeding for 52 weeks totally.Results: By the end of the experiment

the number of complex plaques

Crouse integrals

intima-media thickness

serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P < 0. 05).Conclusion: Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.

Abstract

and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA

with the observation proceeding for 52 weeks totally.Results: By the end of the experiment

the number of complex plaques

Crouse integrals

intima-media thickness

关键词

garlicinprimary hypertensioncoronary heart diseaseAtherosclerotic Plaqueintercellular adhesion molecule-1high sensitive C-reactive protein

Keywords

garlicinprimary hypertensioncoronary heart diseaseAtherosclerotic Plaqueintercellular adhesion molecule-1high sensitive C-reactive protein

references

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Commitee of Drawing up China Guidelines for Management of Primary Hypertension. China guidelines for management of primary hypertension. Chin J Hyperten 2000;8(1): 94–102.

Williams SV, Fihn SD, Gibbous RT. Guidelines for the management of plaques with chronic stable angina: diagnosis and risk stratification. Am Intern Med 2001;135(7): 530–547.

China Integrative Medical Association, Branch Association of Cardiovascular Disease. Criterion of differentiation of symptoms and signs of TCM of coronary artery disease. Chin J Integr Tradit West Med 1991;11 (5): 257.

Issued by Ministry of Heath, People’s Republic of China. Guiding principle of clinical research of new drugs of traditional Chinese medicine (draft). Part I. 1993: 24–29.

Rohani M, Jogestrand T, Ekberg M, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis 2005;179(2): 311–316.

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Department of Integrative Cardiology, China-Japan Friendship Hospital

Department of Cardiology, China-Japan Friendship Hospital

Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Academy of Chinese Medical Sciences

Department of Cardiology, Guang’anmen Hospital

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