Objective: To study the effect of Chinese herbal medicine Gutai Decoction (GTD) on the abortion rate ofin vitro fertilization and embryo transfer (IVF-ET).Methods: Observed were two hundred and forty-seven women having received IVF-ET and with β-human chorionic gonadotropin (β-HCG) > 25 IU/L on the 14th day after transferring. All were treated conventionally with progesterone 20 –80 mg per day after transferring and if necessary the treatment was supplemented with Progynova 2 –4 mg per day

with the medication withdrawn gradually from the 9th week of pregnancy till stopped completely. Among them 131 cases received GTD medication additionally

for 109 cases of whom the medication started from the 2nd day of transferring (taken as Group A) and for the other 22 cases from the 14th day after transferring (taken as Group B)

the other 116 cases with no additional GTD treatment given were taken as the control group

with the medication lasting to the 12th week. The abortion rate in them was observed.Results: The abortion rate in Group A

Group B and the control group was 12.84%

13.64% and 23.28%

respectively

the difference between the GTD treated groups and the control group was significant (P < 0.05).Conclusion: Chinese medicine GTD could reduce abortion rate in women receiving IVF-ET.