Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats

He Wei; Xu Xiao-jun

doi:10.1007/BF02836523

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Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats

Updated：2021-08-27

- Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats
- Chinese Journal of Integrative Medicine Vol. 12, Issue 3, Pages: 203-206(2006)
- Affiliations：
  
  1. Department of Pharmacology, Gannan Medical College,Jiangxi
  2. Department of Pharmacy, Affiliated Hospital of Gannan Medical College,China
- Author bio：
- Funds：
  
  Supported by Jiangxi Provincial Administration Bureau of Traditional Chinese Medicine (No. 020048, 2002A35)
- DOI：10.1007/BF02836523
  CLC：
- Published：2006，
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Wei, H., Xiao-jun, X. Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats., Chin. J. Integr. Med. 12, 203–206 (2006). https://doi.org/10.1007/BF02836523

He Wei, Xu Xiao-jun. Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats. [J]. Chinese Journal of Integrative Medicine 12(3):203-206(2006)
Wei, H., Xiao-jun, X. Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats., Chin. J. Integr. Med. 12, 203–206 (2006). https://doi.org/10.1007/BF02836523 DOI：

He Wei, Xu Xiao-jun. Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats. [J]. Chinese Journal of Integrative Medicine 12(3):203-206(2006) DOI： 10.1007/BF02836523.

摘要

Objective: To investigate the neuro-protective effect of Xuesaitong Injection XST on brain inflammatory response after transient focal cerebral ischemia/reperfusion in rats.Methods: Focal cerebral ischemia/reperfusion models of male rats were induced by transient occlusion for 2 h of middle cerebral artery (MCA) which was followed by 24 h reperfusion. XST was administered through intraperitoneal injection of 25 mg/kg or 50 mg/kg at 4 h after the onset of ischemia. After reperfusion for 24 h

the neurological function score was evaluated

the brain edema was detected with dry-wet weight method

the myeloperoxidase (MPO) activity and the expression of intercellular adhesion molecule-1 (ICAM-1) of ischemic cerebral cortex and caudate putamen was determined by spectrophotometry and immunohistochemistry respectively.Results: XST not only lowered neurological function score at the dose of 50 mg/kg

but reduced brain edema and inhibited MPO activity and ICAM-1 expression as compared with the ischemia/reperfusion model group (P < 0.01).Conclusion: XST has a definite effect on inhibiting the expression of ICAM-1 and neutrophil infiltration in rats with cerebral ischemia/reperfusion when treatment started at 4 h after ischemia onset

and also attenuates inflammation in the infarcted cerebral area.

Abstract

the neurological function score was evaluated

the brain edema was detected with dry-wet weight method

and also attenuates inflammation in the infarcted cerebral area.

关键词

Xuesaitong Injectiontotal saponins of panax notoginsengCerebral Ischemiabrain injuryneutrophilintercellular adhesion molecule-1

Keywords

Xuesaitong Injectiontotal saponins of panax notoginsengCerebral Ischemiabrain injuryneutrophilintercellular adhesion molecule-1

references

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Barone FC, Schmidt DB, Hillegass LM, et al. Reperfusion increases neutrophils and leukatriene B4 receptor binding in rat focal ischemia. Stroke 1992;23 (9): 1337–1347.

Matsuo Y, Onodera H, Shiga Y, et al. Correlation between myeloperoxidase quantified neutrophil accumulation and ischemic brain injury in the rat: Effect of neutrophil depletion. Stroke 1994;25 (7): 1469–1475.

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Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20 (1): 84–91.

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