Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia

Xue Jun; Liu Mei; Chen Jing-he

doi:10.1007/BF02836526

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Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia

Updated：2021-08-27

- Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia
- Chinese Journal of Integrative Medicine Vol. 12, Issue 3, Pages: 215-217(2006)
- Affiliations：
  
  1. Department of Science and Technique, Guangzhou University of TCM,Guangzhou
  2. The First Affiliated Hospital of Guangzhou University of TCM,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836526
  CLC：
- Published：2006，
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Jun, X., Mei, L. & Jing-he, C. Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia., Chin. J. Integr. Med. 12, 215–217 (2006). https://doi.org/10.1007/BF02836526

Xue Jun, Liu Mei, Chen Jing-he. Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia. [J]. Chinese Journal of Integrative Medicine 12(3):215-217(2006)
Jun, X., Mei, L. & Jing-he, C. Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia., Chin. J. Integr. Med. 12, 215–217 (2006). https://doi.org/10.1007/BF02836526 DOI：

Xue Jun, Liu Mei, Chen Jing-he. Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia. [J]. Chinese Journal of Integrative Medicine 12(3):215-217(2006) DOI： 10.1007/BF02836526.

摘要

Objective: To observe the effect of Kaixin Capsule (KXC) on myocardial ischemia and plasma endothelin (ET) level in patients with diabetic heart disease (DHD).Methods: The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine

and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC

with the therapeutic course for both groups as 60 days.Results: On ECG

the total effective rate and markedly effective rate in the treated group was 85. 0% and 37. 5% respectively

higher than those in the control group’s 68.7% and 28.1% respectively

and showing significant difference between the two groups (P < 0.05). The level of ET in patients in both groups was significantly higher than normal range

after treatment

but reduced to different extent

and the comparison between them also showed that the difference was significant (P < 0.05).Conclusion: KXC might

by way of inhibiting and blocking the release of ET

lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.

Abstract

and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC

with the therapeutic course for both groups as 60 days.Results: On ECG

the total effective rate and markedly effective rate in the treated group was 85. 0% and 37. 5% respectively

higher than those in the control group’s 68.7% and 28.1% respectively

and showing significant difference between the two groups (P < 0.05). The level of ET in patients in both groups was significantly higher than normal range

after treatment

but reduced to different extent

and the comparison between them also showed that the difference was significant (P < 0.05).Conclusion: KXC might

by way of inhibiting and blocking the release of ET

lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.

关键词

diabetic heart diseaseMyocardial ischemiaendothelinKaixin Capsule

Keywords

diabetic heart diseaseMyocardial ischemiaendothelinKaixin Capsule

references

Chen KJ. Studies of cardiovascular diseases. Shanghai: Shanghai Scientific and Technical Publishers, 1998: 58.

Wang RY, Su SO, Liu WS, et al. Study of relationship between plasmic levels of endothelin and hemodynamic changes in 74 patients with diabetes mellitus. J New Chin Med 2000;31(8): 465–466.

Hopfner RL, Gopalakrishnan V. Endothelin: emerging role in diabetic vascular complications. Diabetologia 1999;42(12): 1383–1394.

Mangiafico RA, Malation LS, Santonocito M, et al. Plasma endothelin-1 concentration in non-insulin-dependent diabetes mellitus and nondiabetes patients with chronic arterial obstructive disease of the lower limbs. Int Angiol 1998;17(2): 97–102.

Xue J, Luo XX, Chen JH. Influence of Kaixin Capsule on myocardial ischemia and endothelin in rats with diabetes mellitus. J New Chin Med 1999;31(6): 34–35.

Xue J, Chen JH. Preliminary study on TCM pathogenesis of diabetic heart disease. J Tradit Chin Med 2002;43(4): 248–249.

Xue J, Luo XX, Chen JH. Influence of Chinese herbal drug on myocardial ischemia and plasma insulin level in rats with diabetes. J Emerg Syndromes Tradit Chin Med 1998;7(6): 269–271.

Xue J, Luo XX, Chen JH. Effects of Kaixin Capsule on blood rheology of rats with myocardial ischemia and diabetes mellitus. Tradit Chin Drug Res Clin Pharmacol 1999;10(6): 349–351.

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