Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis

Yang Dong-xia; Ma Wen-guang; Qu Fan; Ma Bao-zhang

doi:10.1007/BF02836527

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Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis

Updated：2021-08-27

- Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis
- Chinese Journal of Integrative Medicine Vol. 12, Issue 3, Pages: 218-220(2006)
- Affiliations：
  
  Department of Gynecology, Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin
- Author bio：
- Funds：
  
  Supported by the Fund of Natural Sciene of Heilongjiang Province (2004-D55)
- DOI：10.1007/BF02836527
  CLC：
- Published：2006，
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Dong-xia, Y., Wen-guang, M., Fan, Q. et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis., Chin. J. Integr. Med. 12, 218–220 (2006). https://doi.org/10.1007/BF02836527

Yang Dong-xia, Ma Wen-guang, Qu Fan, et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis. [J]. Chinese Journal of Integrative Medicine 12(3):218-220(2006)
Dong-xia, Y., Wen-guang, M., Fan, Q. et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis., Chin. J. Integr. Med. 12, 218–220 (2006). https://doi.org/10.1007/BF02836527 DOI：

Yang Dong-xia, Ma Wen-guang, Qu Fan, et al. Comparative study on the efficacy of Yiweining and gestrinone for post-operational treatment of stage III endometriosis. [J]. Chinese Journal of Integrative Medicine 12(3):218-220(2006) DOI： 10.1007/BF02836527.

摘要

Objective: To observe the clinical efficacy and safety of Yiweining

(YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).Methods: Fifty-two patients of EM-III after operation were randomly assigned into three groups

the YWN group (20 patients) was treated through oral intake of YWN 200 ml

twice a day;the GT group (19 patients) treated with gestrinone 2.5 mg

twice every week

with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course

and follow-up study was carried out in the 6 –30 months after the end of the medication.Results: The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively

showing insignificant difference between the two groups

but they were lower than that in the control group (30.7%

P < 0.05). Besides

the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%

P < 0.05).Conclusion: Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe

and its efficacy is similar to that of GT.

Abstract

Objective: To observe the clinical efficacy and safety of Yiweining

(YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).Methods: Fifty-two patients of EM-III after operation were randomly assigned into three groups

the YWN group (20 patients) was treated through oral intake of YWN 200 ml

twice a day;the GT group (19 patients) treated with gestrinone 2.5 mg

twice every week

with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course

and follow-up study was carried out in the 6 –30 months after the end of the medication.Results: The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively

showing insignificant difference between the two groups

but they were lower than that in the control group (30.7%

P < 0.05). Besides

the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%

P < 0.05).Conclusion: Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe

and its efficacy is similar to that of GT.

关键词

endometriosis after operationYiweininggestrinone

Keywords

endometriosis after operationYiweininggestrinone

references

American Fertility Society. Revised American fertility society classification of endometriosis: 1985. Fertil Steril 1985; 43(3): 351–352.

Shu J, Fang SH, Sheng LF, et al. Clinical observation on the effects of mifepristone and gestrinone treatment for postoperative patients with severe pelvic endometriosis. Chin J Pract Gynecol Obstet 2002;18(3): 181–183.

Blumenfeld Z. Hormonal suppressive therapy for endometriosis may not improve patient health. Fertil Steril 2004;81 (3): 487–492.

Cao YZ, editor. Chinese obstetrics and gynecology. Beijing: People’s Medical Publishing House, 1999: 1291

Situ Y, Yang JL. Special edition of gynecopathy. Clinical diagnosis and therapy series of traditional Chinese medicine. 2nd ed. Beijing: People’s Medical Publishing House, 2005: 635.

Xu BS, Cai YP, Li Y, et al. Expression of Bcl-2 in eutopic and ectopic endometrium of EMT model rats treated with traditional Chinese medicine. Chin J Histochem Cytochem 2004;13(4): 489–493.

Yu XH, Huang GY, Lu FE, et al. Effect of promote-bloodflow decoction on proliferation of ectopic endometrim cells in an endometriosis rat model. J Huazhong Univ Sci Technol (Health Sci) 2006;35(1): 93–95.

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