Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients

Zhao Hai-bin; Shen Cheng-ling

doi:10.1007/BF02836550

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Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients

Updated：2021-08-27

- Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients
- Chinese Journal of Integrative Medicine Vol. 10, Issue 1, Pages: 10-13(2004)
- Affiliations：
  
  1. Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing
  2. Beijing University of Chinese Medicine,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836550
  CLC：
- Published：2004，
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Hai-bin, Z., Cheng-ling, S. Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients., Chin. J. Integr. Med. 10, 10–13 (2004). https://doi.org/10.1007/BF02836550

Zhao Hai-bin, Shen Cheng-ling. Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients. [J]. Chinese Journal of Integrative Medicine 10(1):10-13(2004)
Hai-bin, Z., Cheng-ling, S. Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients., Chin. J. Integr. Med. 10, 10–13 (2004). https://doi.org/10.1007/BF02836550 DOI：

Zhao Hai-bin, Shen Cheng-ling. Intervention effect of Jianxin Decoction on serum cytokine level of congestive heart failure patients. [J]. Chinese Journal of Integrative Medicine 10(1):10-13(2004) DOI： 10.1007/BF02836550.

摘要

Objective: To investigate the intervention effect of Jianxin Decoction on the cytokine level in serum of patients with congestive heart failure (CHF).Methods: Sixty-six patients with CHF were randomly divided into the control group (n = 33) and the trial group (n = 33). The control group received conventional treatment

and the trial group was treated with conventional therapy plus JXD for 4 weeks. Before and after treatment

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) and nitrogen monoxide (NO) in serum and cardiac function were determined.Results; After treatment

the levels of TNF-α

IL-6 and NO were significantly lower than those before treatment (P<0.05

or P<0.01) in the two groups

and the lowering degree of the indices in the trial group was more significantly reduced than that in the control group (P<0. 05). And cardiac functions in both groups were improved significantly ({otP}<0. 05

orP< 0.01).Conclusion: JXD could prevent and reverse ventricular remodeling so as to ameliorate cardiac function through regulating the levels of cytokines.

Abstract

and the trial group was treated with conventional therapy plus JXD for 4 weeks. Before and after treatment

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) and nitrogen monoxide (NO) in serum and cardiac function were determined.Results; After treatment

the levels of TNF-α

IL-6 and NO were significantly lower than those before treatment (P<0.05

or P<0.01) in the two groups

orP< 0.01).Conclusion: JXD could prevent and reverse ventricular remodeling so as to ameliorate cardiac function through regulating the levels of cytokines.

关键词

congestive heart failureinterleukin-6tumor necrosis factor-αnitrogen monoxidecardiac functionJianxin decoction

Keywords

congestive heart failureinterleukin-6tumor necrosis factor-αnitrogen monoxidecardiac functionJianxin decoction

references

Chen GW, Zheng ZE. Modern cardiac internal medicine. 2nd ed. Changsha: Hunan Science and Technology Publishing House, 2002: 735, 744–767.

Gao DS, Dong DJ. Clinical cardiovascular diseases. 1st ed. Jinan: Shandong Science and Technology Publishing House, 2000: 8.

Ministry of Health of the People’s Republic of China. Guidance principle of clinical study on new Chinese medicine. 1st ed. 1993: 57.

Zhao JD, Zhang JR, Zhang Z. Differentiation diagnostics of syndromes in tradional Chinese medicine. Beijing: Peoplés Medical Publishing House, 1987: 35–38.

Goldhaber JI, Kin KH, Natterson PD, et al. Effect of TNF-α on [Ca2+]i and contractility in isolated adult rabbit ventricular myocytes. AM J Physiol 1996; 271 (4): 1449–1455.

Yang LX. Study development of cytokines network and heart failure. Develop Cardiovas Dis 2002;23(1): 16.

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Related Institution

Beijing Institute of Traditional Chinese Medicine

Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University

Department of Traditional Chinese Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University

Department of Hepatology, Zhejiang Hospital of Traditional Chinese Medicine

Department of the Integrated Chinese and Western Medicine, Shaanxi Province Traditional Chinese Medical Key Department of Nephrology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University

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