Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis

Xu Feng-qin; Li Li-zhi; Xu Hao; Yao Li-fang; Chen Ke-ji; Shao Nian-fang

doi:10.1007/BF02836551

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Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis

Updated：2021-08-27

- Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis
- Chinese Journal of Integrative Medicine Vol. 10, Issue 1, Pages: 14-18(2004)
- Affiliations：
  
  1. Xiyuan Hospital, China Academy of Traditional Chinese Medicine
  2. The Affiliated Hospital to Shandong University of TCM,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836551
  CLC：
- Published：2004，
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Feng-qin, X., Li-zhi, L., Hao, X. et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis., Chin. J. Integr. Med. 10, 14–18 (2004). https://doi.org/10.1007/BF02836551

Xu Feng-qin, Li Li-zhi, Xu Hao, et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis. [J]. Chinese Journal of Integrative Medicine 10(1):14-18(2004)
Feng-qin, X., Li-zhi, L., Hao, X. et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis., Chin. J. Integr. Med. 10, 14–18 (2004). https://doi.org/10.1007/BF02836551 DOI：

Xu Feng-qin, Li Li-zhi, Xu Hao, et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis. [J]. Chinese Journal of Integrative Medicine 10(1):14-18(2004) DOI： 10.1007/BF02836551.

摘要

Objective:To study the effect of Xiongshao Capsule (XSC)

a TCM herb that can promote blood circulation to remove blood stasis

on the endothelial dependent relaxation function

serum nitric oxide (NO)

and plasma endothelin-KET-1) of the patients with cervical atherosclerosis.Methods: Forty patients were randomly divided into two groups: XSC group and Probucol group (western medicine control). In addition

20 healthy people were set as a normal control group. Plasma ET-1

serum NO

the internal diameter of basal brachial artery

endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results: Compared to the healthy control group

FMD of patients with atherosclerosis was damaged obviously

the serum NO level decreased

plasma ET-1 increased (P< 0.01)

NID also decreased (P<0.05)

the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks

FMD increased evidently

plasma ET-1 decreased

serum NO and the ratio of NO/ET-1 increased

compared with the level before therapy and Probucol group

the difference was significant (P<0.05

P<0.01)

NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.

Abstract

Objective:To study the effect of Xiongshao Capsule (XSC)

a TCM herb that can promote blood circulation to remove blood stasis

on the endothelial dependent relaxation function

serum nitric oxide (NO)

20 healthy people were set as a normal control group. Plasma ET-1

serum NO

the internal diameter of basal brachial artery

FMD of patients with atherosclerosis was damaged obviously

the serum NO level decreased

plasma ET-1 increased (P< 0.01)

NID also decreased (P<0.05)

the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks

FMD increased evidently

plasma ET-1 decreased

serum NO and the ratio of NO/ET-1 increased

compared with the level before therapy and Probucol group

the difference was significant (P<0.05

P<0.01)

NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.

关键词

atherosclerosisendothelial vasodilator functionXiongshao capsule

Keywords

atherosclerosisendothelial vasodilator functionXiongshao capsule

references

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Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University

Lab, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou

Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University

Zhujiang Hospital, Southern Medical University

Integrative Hospital, College of Chinese Medicine, Southern Medical University

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